Umweltrelevante Arzneimittel

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The presence of active pharmaceutical ingredients (API) in the environment has been a growing concern in recent years. Around 2300 different API are being administered, and it is estimated that more than 8 000 t of drugs are being consumed - annually alone in Germany. 1200 of these pharmaceuticals are considered environmentally relevant since they are Persistent, Bioaccumulative or Toxic (PBT). So far 150 different API have been detected in waste water effluents, in surface water, ground water and drinking water in Germany. Even though the concentrations are very low (ng/L to µg/L) they may cause a threat not only to aquatic and terrestrial organisms but also to human health. Together with the University of Gdańsk and the group of Prof. Piotr Stepnowski we are investigating the environmental behaviour of several different types of drugs such as antibiotics, anti-diabetics, anthelmintics, beta-blockers, anti-inflammatoy drugs and contraceptives. Thereby we address various research topics:

  •        development of analytical methods
  •        ecotoxicity assessment of pharmaceuticals, their mixtures and their transformation products
  •        abiotic and biotic degradability under various environmental conditions
  •        elucidation of degradation pathways
  •        waste water treatment


For further information please have a look at our recent publications:

Wagil M. et al. (2015) Toxicity of anthelmintic drugs (fenbendazole and flubendazole) to aquatic organisms. Environmental Science and Pollution Research 22, 2566–2573. Free full text available under: ResearchGate

Wagil M., et al. (2014) Development of sensitive and reliable LC-MS/MS methods for the determination of three fluoroquinolones in water and fish tissue samples and preliminary environmental risk assessment of their presence in two rivers in northern Poland. Science of the Total Environment 493, 1006–1013. Free full text available under: ResearchGate

Fabianska A., et al. (2014) Electrochemical degradation of sulfonamides at BDD electrode: kinetics, reaction pathway and eco-toxicity evaluation. Journal of Hazardous Materials 280, 579–587. Free full text available under: ResearchGate

Maszkowska J., et al. (2014) Beta-blockers in the environment: Part I. Mobility and hydrolysis study. Science of the Total Environment 493, 1112–1121. Free full text available under: ResearchGate

Kolodziejska M., et al. (2013) Aquatic toxicity of four veterinary drugs commonly applied in fish farming and animal husbandry. Chemosphere 92(9), 1253-1259. Free full text available under: ResearchGate


 Dr. Stefan Stolte