Westphal A, Zapf A, Brannath W (2019). A multiple testing framework for diagnostic accuracy studies with co-primary endpoints. (

Saha S, Brannath W, Bornkamp B (2020). Testing multiple dose combinations in clinical trials. Statistical Methods in Medical Research, 29(7): 1799–1817 (


Bader A, Toenjes A, Wielki N, Mandle A, Onken AK, von Hehl A, Meyer D, Brannath W, Tracht K (2019). Parameter Optimization in High-Throughput Testing for Structural Materials, MATERIALS, 12(20), Article 3439

Westphal M, Brannath W (2019). Improving Model Selection by Employing the Test Data. PMLR 97:6747-6756 (

Westphal M, Brannath W (2019). Evaluation of multiple prediction models: A novel view on model selection and performance assessment. Statistical Methods in Medical Research, 29(6):1728-1745. (

Schmidt S, Brannath W (2019). Simultaneous confidence intervals for ratios with application to the gold standard design with more than one experimental treatment. Statistics in Medicine, 38(28): 5350--5360 (

Nhacolo A, Brannath W (2019). Interval and point estimation in adaptive Phase II trials with binary endpoint. Statistical Methods in Medical Research, 28(9):  2635--2648 (

Vradi E, Jaki T, Vonk R, Brannath W (2019). A Bayesian model to estimate the cutoff and the clinical utility of a biomarker assay. Statistical Methods in Medical Research, 28(8): 2538--2556 (

Jaki T, Gordon A, Forster P, Bijnens L, Bornkamp B, Brannath W, Fontana R, Gasparini M, Hampson LV, Jacobs T, Jones B, Paoletti X, Posch M, Titman A, Vonk R, Koenig F (2019). Response to comments on "Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development, Pharmaceutical Statistics, 17(5):593-606", Pharmaceutical Statistics, 18(3): 284-286 (

Wilinska J, Mocanu B, Awad D, Gousia D, Hillner C, Brannath W, Mohr A, Gabel D (2019). New stains for anterior capsule surgery. Journal of Cataract and Refractive Surgery 45(2):213-218 (

Saha S, Brannath W (2019). Comparison of different approaches for dose response analysis. Biometrical Journal, 61(1):83-100. (


Jaki T, Gordon A, Forster P, Bijnens L, Bornkam, B, Brannath W, Fontana R, Gasparini M, Hampson L, Jacobs T, Jones B, Paoletti X, Posch M, Titman A, Vonk R, Koenig F (2018). A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharmaceutical Statistics 17(5):593-606. (

Brückner M, Burger U, Brannath W (2018). Non-parametric adaptive enrichment designs using categorical surrogate data. Statistics in Medicine, 39(29):4507-4524. (

Awad D, Wilinska J, Gousia D, Shi XY, Eddous J, Mueller A, Wagner V, Hillner C, Brannath W, Mohr A, Gabel D (2018). Toxicity and phototoxicity in human ARPE-19 retinal pigment epithelium cells of dyes commonly used in retinal surgery. European Journal of Ophthalmolog. 28(4):433-440. (

Vradi E, Brannath W, Jaki T, Vonk R (2018). Model selection based on combined penalties for biomarker identification. Journal of Biopharmaceutical Statistics, 28(4):735-749. (

Kerkemeyer L, Wasem J, Neumann A, Brannath W, Mester B, Timm J, Wobrock T, Bartels C, Falkai P, Biermann J. (2018). Effectiveness and cost-effectiveness of an integrated care program for schizophrenia: an analysis of routine data. Eur Arch Psychiatry Clin Neurosci, Europaen archives of pschiatry and clinical neuro science, 265(2):155–162 (

Jaki T, Gordon A, Bijnens L, Bornkamp B, Brannath W, Fontana R, Gasparini M, Hampson LV, Jacobs T, Jones B, Paoletti X, Posch M, Titman A, Vonk R, Koenig F (2019). A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharmaceutical Statistics, 17(5):593-606. (


Brannath W (2017). Contribution to the discussion of “A critical evaluation of the current ‘p-value controversy’”. Biometrical Journal, 59(5):875-876. (

Nitsche M, Brannath W, Brueckner M, Wagner D, Kaltenborn A, Temme N, Hermann RM (2017). Comparison of different contouring definitions of the rectum as organ at risk (OAR) and dose-volume parameters predicting rectal inflammation in radiotherapy of prostate cancer: which definition to use? British Journal of Radiology, 90(1070), Article No.\ 20160370. (

Brückner M, Brannath W (2017). Sequential tests for non-proportional hazards data. Lifetime Data Analysis, 23:339–352. (

Gutjahr G, Bornkamp B (2017). Likelihood Ratio Tests for a Dose-Response Effect using Multiple Nonlinear Regression Models. Biometrics, Journal of the International Biometric Society 73(1): 197-205. (

Vethaak AD, Davies IM, Thain JE, Gubbins MC, Martínez-Gómez C, Robinson CD, Moffat CF, Burgeot T, Maes T, Wosniok W, Giltrap M, Lang T, Hylland K (2017). Integrated indicator framework and methodology for monitoring and assessment of hazardous substances and their effects in the marine environment. Marine Environmental Research, 124:11-20. (


Wassmer G, Brannath W (2016). Group Sequential and Confirmatory Adaptive Designs in Clinical Trials. Springer Series in Pharmaceutical Statistics, Springer, Swizerland.

Dieckmann K-P, Spiekermann M, Balks T, Ikogho R, Anheuser P, Wosniok W, Loening T, Bullerdiek J, Belge G (2016). MicroRNA miR-371a-3p – A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. Urol Int. 97(1):76-83 (

Gabriel  KMA, Kuechly HU, Falchi F, Wosniok W, Hölker F (2016). Resources of dark skies in German climatic health resorts. Int J Biometeorol 61(1):11-22 (

Hofmann F, Kruse-Plass M, Kuhn U, Otto M, Schlechtriemen U, Schröder B, Vögel R, Wosniok W (2016). Accumulation and variability of maize pollen deposition on leaves of European Lepidoptera host plants and relation to release rates and deposition determined by standardised technical sampling. Environ Sci Eur 28(1):14 (

Haeckel R, Wosniok W, Arzideh F (2016). Equivalence limits of reference intervals for partitioning of population data. Relevant differences of reference limits. LaboratoriumsMedizin 40(3): 199–205 (

Haeckel R, Wosniok W, Gurr E, Peil B (2016). Supplements to a recent proposal for permissible uncertainty of measurements in laboratory medicine.  LaboratoriumsMedizin 40(2): 141–145 (

Hoffmann G, Lichtinghagen R, Wosniok W (2016). Simple estimation of reference intervals from routine laboratory data. J Lab Med 39(6) 389-402 (

Lang T, Kruse R, Haarich M, Wosniok W (2016). Mercury species in dab (Limanda limanda) from the North Sea, Baltic Sea and Icelandic waters in relation to host-specific variables. Marine Environmental Research 124:32-40 (

Schröder W, Nickel S, Schönrock S, Meyer M, Wosniok W, Harmens H, Frontasyeva MV, et al. (2016). Spatially valid data of atmospheric deposition of heavy metals and nitrogen derived by moss surveys for pollution risk assessments of ecosystems. Environ Sci Pollut Res. 23(11):10457-76 (

Wullschleger A, Wosniok W, Timm J, Heinze M (2015). Subscription Rates of Psychiatric Patients to an Integrated Care Program in the Context of a Psychiatric Model Project. Psychiatrische Praxis, 43(7):374-379.

Zutt M, Rudolph H, Kaune  KM, Wosniok W, Gärtner U, Linke R (2016). Myocardial scintigraphy – a method for detecting cardiac comorbidity in psoriasis patients? Journal of the German Society of Dermatology, Journal of the German Society of Dermatology, epub ahead of print  (

Graf A, Gutjahr G, Brannath W (2016). Precision of maximum likelihood estimation in adaptive designs. Statistics in Medicine, 35(6): 922-941 (


Carreras M, Gutjahr G, Brannath W (2015). Adaptive seamless designs with interim treatment selection: a case study in oncology. Statistics in Medicine, 34(8):1317-1333.

Kerkemeyer L, Mostardt S, Biermann J, Wasem J, Neumann A, Walendzik A, Jahn R, Bartels C, Falkai P, Brannath W, Breunig-Lyriti V, Mester B, Timm J, Wobrock T (2015). Evaluation of an integrated care program for schizophrenia: concept and study design. Europaen archives of pschiatry and clinical neuro science, 265(2):155-162.

Schmidt S, Brannath W  (2015). Informative simultaneous confidence intervals for the fall-back procedure. Biometrical Journal, 57(4):712–719.

Hoffmann G, Lichtinghagen R, Wosniok W (2015). Ein einfaches Verfahren zur Schätzung von Referenzintervallen aus routinemäßig erhobenen Labordaten. J Lab Med 39(6):389-402 . (DOI: 10.1515/labmed-2015-0082).

Schumacher TC, Aminian A, Volkmann E, Lührs H, Zimnik D, Pede D, Wosniok W, Treccani L, Rezwan K. (2015). Synthesis and mechanical evaluation of Sr-doped calcium-zirconium-silicate (baghdadite) and its impact on osteoblast cell proliferation and ALP activity. Biomedical Materials 10(5):055013. (DOI: 10.1088/1748-6041/10/5/055013).

Keddig N, Schubert S, Wosniok W (2015). Optimal test design for binary response data: the example of the fish embryo toxicity test. Environmental Sciences Europe 27:15. (DOI: 10.1186/s12302-015-0046-5).

Kloth L, Gottlieb A, Helmke B, Wosniok W, Löning T, Burchardt K, Belge G, Günther K, Bullerdiek J (2015). HMGA2 expression distinguishes between different types of postpubertal testicular germ cell tumour. The Journal of Pathology: Clinical Research, 1(4): 239-251. (DOI: 10.1002/cjp2.26).

Haeckel R, Wosniok W, Postma T (2015). Quantity quotient reporting. Comparison of various models. Clin Chem Lab Med, 53(12):1921-6. (DOI: 10.1515/cclm-2015-0101).

Haeckel R, Wosniok W, Streichert T (2015). Optimizing the use of the “state-of-the-art” performance criteria. Clin Chem Lab Med, 53(6):887–891. (DOI: 10.1515/cclm-2014-1201).

Haeckel R, Wosniok W, Gurr E, Peil B (2015). Permissible limits for uncertainty of measurement in laboratory medicine. Clin Chem Lab Med 53(8):1161-71. (DOI: 10.1515/cclm-2014-0874).


Schmidt S, Brannath W (2014). Informative simultaneous confidence intervals in hierarchical testing. Methods of Information in Medicine, 53(4):278–283

Brannath W, Schmidt S (2014). A new class of powerful and informative simultaneous confidence intervals. Statistics in Medicine, 33(19):3365–3386

Rauch G, Jahn-Eimermacher A, Brannath W, Kieser M. (2014). Opportunities and challenges of combined effect measures based on prioritized outcomes. Statistics in Medicine, 33(7): 1104-1120

Bowden J, Brannath W, Glimm E (2014). Empirical Bayes estimation of the selected treatment mean for two-stage drop-the-loser trials: a meta-analytic approach. Statistics in Medicine, 33(3): 388-400

Schneider S, Kloimstein P, Pammer J, Brannath W, Grasl MC, Erovic BM (2014). New diagnostic markers in salivary gland tumors. European Archives of Oto-Rhino-
Laryngology, 271(7):1999-2007


Schlömer P, Brannath W (2013). Group sequential designs for three-arm ’gold standard’ non-inferiority trials with fixed margin. Statistics in Medicine, 32(28):4875-4889

Wang SJ, Brannath W, Brueckner M, Hung HML, Koch A (2013). Unblinded Adaptive Statistical Information Design Based on Clinical Endpoint or Biomarker. Statistics in Biopharmaceutical Research, 5(4):293-310

Gutjahr G, Brannath W (2013). Multiple tests of cost-effectiveness angles. Statistics in Medicine, 32(10):1754-176230.

Carreras M, Brannath W (2012). Shrinkage estimation in two-stage adaptive designs with mid-trial treatment selection. Statistics in Medicine, 32(10):1677-1690

Urquizo M, Bobrov P, Brannath W (2013). Hybrid Simulation. In: Micro Metal Forming. Ed.: F. Vollerstsen, Springer Berlin, p. 347-359. (ISBN 978-3-642-30915-1)

Lassnigg A, Hiesmayr M, Frantal S, Brannath, W, Mouhieddine M, Presterl E, Isetta C, Bachmann, LM, Andreas M, Seitelberger R, Schmidlin D (2013). Long-term absolute
and relative survival after aortic valve replacement A prospective cohort study. European Journal of Anaesthesiology, 30(11):695-703

Aggermann T, Brunner S, Krebs I, Haas P, Womastek I, Brannath W, Binder S, ROVO Study Group (2013). A prospective, randomised, multicenter trial for surgical treatment of central retinal vein occlusion: results of the Radial Optic Neurotomy for Central Vein cclusion. Graefes Archive for Clinical and Experimental Ophthalmology, 251(4):1065-1072

Haeckel R, Wosniok W, Klauke R (2013). Comparison of ordinary linear regression, orthogonal regression, standardized principal component analysis, Deming and Passing-Bablok approach for method validation in laboratory medicine. J Lab Med, 37(3): 147–163. (DOI: 10.1515/labmed-2013-0003).

Grütjen F, Lang T, Feist S, Bruno D, Noguera P, Wosniok W (2013). Hyperpigmentation in North Sea dab Limanda limanda. I. Spatial and temporal patterns and host effects. Dis Aquat Org 103:9-24. (DOI: 10.3354/dao02554).


Brannath W, Gutjahr G, Bauer P (2012). Probabilistic Foundation of Confirmatory Adaptive Designs. Journal of the American Statistical Association, 107:824-832.

Graef, F., Römbke, J., Binimelis, R., Myhr, A.I., Hilbeck, A., Breckling, B., Dalgaard, T., Stachow, U., Catacora-Vargas G., Bøhn, T., Quist, D., Darvas, B., Dudel, G., Oehen, B., Meyer, H., Henle, K., Wynne, B., Metzger, M.J., Knäbe, S., Settele, J., Székács, A., Wurbs, A., Bernard, J., Murphy-Bokern, D., Buiatti, M., Giovannetti, M., Debeljak, M., Andersen, E., Paetz, A., Dzeroski, S., Tappeser, B., van Gestel, C.A.M., Wosniok, W., Séralini, G.-E., Aslaksen, I., Pesch, R., Maly, S., Werner, A. (2012): A framework for a European network for a systematic environmental impact assessment of genetically modified organisms (GMO). BioRisk 7: 73–97. (DOI: 10.3897/biorisk.7.1969).

Salhofer-Polanyi S, Frantal S, BrannathW, Seidel S,Wober-Bingol C,Wober C (2012). Prospective Analysis of Factors Related to Migraine Aura - The PAMINA Study. Headach, 52:1236-1245.

Haeckel R, Wosniok W, Kratochvila J, Carobene A. (2012). A pragmatic proposal for permissible limits in external quality assessment schemes with a compromise between biological variation and state of the art. Clin Chem Lab Med, 50(5):833-839.

Markowski D, Helmke B, Radtke A, Froeb J, Belge G, Bartnitzke S, Wosniok W, Czybulka-Jachertz I, Deichert U, Bullerdiek J (2012). Fibroid explants reveal a higher sensitivity against MDM2-inhibitor nutlin-3 than matching myometrium. BMC Women’s Health 12:2.

Kammann U, Lang T, Wosniok W (2012). Biological effects monitoring in marine research. Environmental Sciences Europe 24:1. (DOI:10.1186/2190-4715-24-1).


Gutjahr G, Posch M, Brannath W. (2011). Familywise error control in multi-armed response-adaptive two-stage designs. Journal of Biopharmceutical Statistics, 21(4):818-30.

Gutjahr G, Brannath W, Bauer P, (2011). An approach to the conditional error rate principle with nuisance parameters. Biometrics, 67(3):1039-46.

Krebs I, Hagen S, Smretschnig E, Womastek I, Brannath W, Binder S. (2011). Reproducibility of segmentation error correction in age-related macular degeneration: Stratus
versus Cirrus OCT. Britisch Journal of Ophthalmology, 96:271-275.

Montalvo-Urquizo J, Bobrov P, Schmidt A, Wosniok W (2011). Elastic responses of texturized microscale materials using FEM simulations and stochastic material properties. Mechanics of Materials, 47:1-10 (DOI: 10.1016/j.mechmat.2011.11.008.

Krebs I, Hagen S, Smretschnig E, Womastek I, Brannath W, Binder S. (2011). Reproducibility of segmentation error correction in age-related macular degeneration: Stratus
versus Cirrus OCT. Britisch Journal of Ophthalmology, 96:271-275.

Krebs I, Hagen S, Smretschnig E, Womastek I, Brannath W, Binder S. (2011). Conversion of Stratus optical coherence tomography (OCT) retinal thickness to Cirrus OCT
values in age-related macular degeneration. Br Journal Ophthalmology, 95(11):1552-1554

Krebs I, Smretschnig E, Moussa S, Moussa S, Brannath W, Womastek I, Binder S (2011). Quality and Reproducibility of Retinal Thickness Measurements in Two Spectral-
Domain Optical Coherence Tomography Machines. Investigative Ophthalmology and Visual Science, 52:6925-6933

Lieba-Samal D, Wöber C, Frantal S, Brannath W, Schmidt K, Schrolnberger C, Wöber-Bingöl C; PAMINA study group. (2011). Headache, menstruation and combined oral
contraceptives: A diary study in 184 women with migraine. Europaen Journal of Pain, 15:852-857

Zebenholzer K, Rudel E, Frantal S, Brannath W, Schmidt K, Wöber-Bingöl C, Wöber C (2011). Migraine and weather: A prospective diary-based analysis. Cephalalgia,

M. Pieper, G. W. Eagleson, W. Wosniok, G. Schlosser (2011): Origin and segregation of cranial placodes in Xenopus laevis. Developmental Biology, 360:257-275.

Kloth L, Belge G, Burchardt K, Loeschke S, Wosniok W, Fu X, Nimzyk R, Mohamed SA, Drieschner N, Rippe V, Bullerdiek J (2011). Decrease in thyroid adenoma associated (THADA) expression is a marker of dedifferentiation of thyroid tissue. BMC Clinical Pathology,11:13. (DOI:10.1186/1472-6890-11-13).

Bobrov P, Montalvo-Urquizo J, Lütjens J, Brannath W, Wosniok W, Schmidt A, Hunkel M (2011). Ein stochastisches Modell zur Rekonstruktion elastischer Eigenschaften für texturierte Metalle. In: O. Kraft, A. Haug, F. Vollertsen, S. Büttgenbach (Hrsg.): Kolloquium Mikroproduktion und Abschlusskolloquium SFB 499, 11. - 12. Oktober 2011, Karlsruhe. KIT SCIENTIFIC REPORTS 7591, 183-189.

Haeckel R, Wosniok W, Al Shareef N (2011). Permissible performance limits of regression analyses in method comparisons. Clin Chem Lab Med, 49(11):1805-16. (DOI 10.1515/CCLM.2011.668).

Lütjens J, Bobrov P, Hunkel M, Wosniok W (2011). Towards a distribution-based formulation of FEM for micro-scale components. Procedia Engineering 10:1663-1669. (DOI:10.1016/j.proeng.2011.04.278).

Gurr E, Arzideh F, Brandhorst G, Gröning A, Haeckel R, Hoff T, Roggenbuck L, Schumann G, Wolters B, Wosniok W (2011). Musterstandardarbeitsanweisung Präanalytik. J Lab Med, 35(1):55-60.

Arzideh F, Wosniok W, Haeckel R (2011). Indirect reference intervals of plasma and serum thyrotropin (TSH) concentrations from intra-laboratory data bases from several German and Italian medical centres. Clin Chem Lab Med, 49(4):659-664.

Haeckel R,  Wosniok W (2011). A new concept to derive permissible limits for analytical imprecision and bias considering diagnostic requirements and technical state-of-the-art. Clin Chem Lab Med 49(4):623–635.


Brannath W, Burger HU, Glimm E, Stallard N, Vandemeulebroecke M, Wassmer G (2010). Comments on the Draft Guidance on Adaptive Design Clinical Trials for Drugs and Biologics of the US Food and Drug Administration. Journal of Biopharmaceutical Statistics, 20(6):1125-1131.

Benda N, Brannath W, Bretz F, Burger HU, Friede T, Maurer W, Wang SJ (2010). Perspectives on the Use of Adaptive Designs in Clinical Trials. Part II. Panel Discussion. Journal of Biopharmaceutical Statistics, 20(6):1098-1112.

Brannath W, Bretz F (2010). Shortcuts for locally consonant closed test procedures. Journal of the American Statistical Association, 105(490):660-669.

Brannath W, Futschik A, Krall C (2010). Statistik im Studium der Wirtschaftswissenschaften. (3., überarbeitete Auflage). Facultas.wuv (ISBN 978-3-7089-0489-4)

Bauer T. Giarrizzo, U. Krumme, W. Wosniok (2010): Size-structured migration and feeding patterns in the banded puffer fish Colomesus psittacus (Tetraodontidae) from north Brazilian mangrove creeks. Marine Ecology Progress Series, 419:157-170. (DOI: 10.3354/meps08852).

Haeckel R, Wosniok W (2010): Observed, unknown distributions of clinical chemical quantities should be considered to be log-normal: a proposal. Clin Chem Lab Med 48(10):1393-1396.

Haeckel R, Wosniok W (2010). Controversies on quotient reporting to standardize laboratory results. Clin Chem Lab Med 48(8):1199-1201.

Hofmann F, Epp R, Kalchschmid A, Kratz W, Kruse L, Kuhn U, Maisch B, Müller E, Ober S, Radtke J, Schlechtriemen U, Schmidt G, Schröder W, v. d. Ohe W, Vögel R, Wedl N, Wosniok W (2010). Monitoring of Bt-Maize pollen exposure in the vicinity of the nature reserve Ruhlsdorfer Bruch in northeast Germany 2007 to 2008. Umweltwiss Schadst Forsch 22(3):229–251. (DOI: 10.1007/s12302-010-0133-6).

Markowski DN, von Ahsen I, Nezhad MH, Helmke BM, Bullerdiek J, Wosniok W (2010). HMGA2 and the p19(Arf)-TP53-CDKN1A Axis: A Delicate Balance in the Growth of Uterine Leiomyomas. Genes Chromosomes & Cancer 49(8):661-668.

Haeckel R, Wosniok W, Hoffmann G (2010). Standardisierung von Laborergebnissen: Ergebnisquotient. J Lab Med, 34(2): 95-98

F. Arzideh, W. Wosniok, R. Haeckel (2010): Reference limits of plasma and serum creatinine concentrations from intra-laboratory data bases of several German and Italian medical centres Comparison between direct and indirect procedures. Clinica Chimica Acta, 411:215-221.

P, Koenig F, Brannath W, Posch M (2010). Selection and bias - Two hostile brothers. Statistics in Medicine, 29(1):1-13

Serbecic N, Aboul-Enein F, Beutelspacher SC, Graf M, Kircher K, Geitzenauer W, Brannath W, Lang P, Kristoferitsch W, Lassmann H, Reitner A, Schmidt-Erfurth U
(2010). Heterogeneous Pattern of Retinal Nerve Fiber Layer in Multiple Sclerosis. High Resolution Optical Coherence Tomography: Potential and Limitations. PLOS
ONE, 5(11):e13877.

Krebs I, Hagen S, Brannath W, Haas P, Womastek I, de Salvo G, Ansari-Shahrezaei S, Binder S (2010). Repeatability and reproducibility of retinal thickness measurements by optical coherence tomography in age-related macular degeneration. Ophthalmology, 117, 8:1577-84.

Boltz A, Luksch A,Wimpissinger B, Maar N,Weigert G, Frantal S, BrannathW, Garhofer G, Ergun E, Stur M, Schmetterer L. (2010). Choroidal Blood Flow and Progression
of Age-Related Macular Degeneration in the Fellow Eye in Patients with Unilateral Choroidal Neovascularization. Investigative Ophthalmology & Visual Science, 51 (8):

Göbl CS, Brannath W, Bozkurt L, Handisurya A, Anderwald C, Luger A, Krebs M, Kautzky-Willer A, Bischof MG (2010). Sex-specific differences in glycemic control
and cardiovascular risk factors in older patients with insulin-treated type 2 diabetes mellitus. Gender Medicine, 7(6):593-9.

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