Glutathione metabolism

Glutathione is a tripeptide that is present in millimolar concentrations in all brain cells. It has essential function in the defence of brain cells against radicals, peroxides and toxins. We investigate the synthesis, consumption, and regeneration of GSH in brain cells, the cooperation of astrocytes and neurons in GSH metabolism, the oxidation of GSH to glutathione disulfide (GSSG), the conjugation of GSH to drugs and toxins, as well as the multidrug-resistance protein-mediated export of GSH, GSSG and GSH conjugates from brain cells.


© Prof. Dr. Ralf Dringen / FB 2
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