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Publications

S. C. H. Ngomtcho, J. S Weber, E. N. Bum, T. T. Gbem, S. Kelm and M. D. Achukwi (2017) Molecular screening of tsetse flies and cattle reveal different Trypanosoma species including T. grayi and T. theileri in northern Cameroon. Parasites and Vectors, 10, 631 doi:10.1186/s13071-017-2540-7

G. Dharmadhikari, K. Stolz, M. Hauke, N. G. Morgan, A. Varki, E. de Koning, S. Kelm, K. Maedler (2017) Siglec-7 restores β-cell function and survival and reduces inflammation in diabetic pancreatic islets. Scientific Reports, 7, 45319, DOI: 10.1038/srep45319

J. Nüße, E.-M. Blumrich, U. Mirastschijski, L. Kappelmann, S. Kelm, F. Dietz (2017) Intra- or extra-exosomal secretion of HDGF isoforms: the extraordinary function of the HDGF-A N-terminal peptide. Biol Chem, 398, 793-811, doi: 10.1515/hsz-2016-0315

P. D. Madge, A. Maggioni, M. Pascolutti, M. Amin, M. Waespy, B. Bellette, R. J. Thomson, S. Kelm, M. von Itzstein, T. Haselhorst (2016). Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy. Scientific Reports, 6, 36012, doi.org/10.1038/srep36012

M. A. Nyangasa, S. Kelm, M. A. Sheikh, A. Hebestreit (1916) Design, Response Rates, and Population Characteristics of a Cross-Sectional Study in Zanzibar, Tanzania. JMIR Research Protocols, 5, 4, e235, doi: 10.2196/resprot.6621

A. Meyer, K. Günther, G. Dharmadhikari, A. Hebestreit, F. Paroni, W. Ahrens, S. Kelm, K. Maedler (2016) An optimized method for human blood sampling and subsequent RNA isolation for large studies. PLOS ONE, 11, 8, e0161778, doi: 10.1371/journal.pone.0161778

J. Nüße, U. Mirastschijski, M. Waespy, J. Oetjen, N. Brandes. O. Rebello, F. Paroni. S. Kelm, F. Dietz (2016) Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton. Biol Chem, 397, 417–436. doi: 10.1515/hsz-2015-0273

M. Waespy, T. T. Gbem, L. Elenschneider, A.-P., C. J. Day, L. Hartley-Tassell, N. Bovin, J. Tiralongo, T. Haselhorst, S. Kelm (2015) Carbohydrate recognition specificity of trans-sialidase lectin domain from Trypanosoma congolense. PLoS Negl Trop Dis. 9, doi:10.1371/journal.pntd.0004120

J. Warneke, M. Plaumann, Z. Wang, E. Böhler, D. Kemken, S. Kelm, D. Leibfritz, V. A. Azov (2015) New insights into the old reaction between pyridine and acryloyl chloride. Tetrahedron Letters 56, 1124-1127. doi:10.1016/j.tetlet.2015.01.100

T. Dodenhof, F. Dietz, S. Franken, I. Grunwald, S. Kelm (2014) Splice variants of Perlucin from Haliotis laevigata modulate the crystallisation of CaCO3. PLoS ONE 9: e97126–e97126. doi:10.1371/journal.pone.0097126.s001.

T.T. Gbem, M. Waespy, B. Hesse, F. Dietz, J. Smith, G. D. Chechet, J. A. Nok, S. Kelm (2013): Biochemical diversity in the Trypanosoma congolense trans-sialidase family. PLoS Negl Trop Dis. 7:e2549. doi: 10.1371/journal.pntd.0002549.

S. Kelm, P. Madge, T. Islam, R. Bennett, H. Koliwer-Brandl, M. Waespy, M. v. Itzstein, T. Haselhorst (2013): C-4 Modified Sialosides Enhance Binding to Siglec-2 (CD22): Towards Potent Siglec Inhibitors for Immunoglycotherapy. Angewandte Chemie International Edition, 52, 3616–3620, DOI:10.1002/anie.201207267

S. Dauth, M. M. Schmidt, M. Rehders, F. Dietz, S. Kelm, R. Dringen, K. Brix (2012): Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice. Biol. Chem. 393, 959-970, DOI 10.1515/hsz-2012-0145.

M. Visa, E. Hammer, U. Völker, H. Koliwer-Brandl, S. Kelm, S.K. Nadimpalli (2012): Purification and biochemical characterization of a lysosomal α-fucosidase from the deuterostomia Asterias rubens. Biochimie 94, 1199-205, DOI: 10.1016/j.biochi.2012.02.007.

K. Thakar, I. Votteler, D. Kelkar, T. Shidore, S. Gupta, S. Kelm, F. Dietz (2012): HRP-2 isoforms interact with HDGF: Chromatin binding of a specific heteromer. FEBS J. 279, 737-751, DOI: 10.1111/j.1742-4658.2011.08464.x

S. Mesch, K. Lemme, M. Wittwer, H. Koliwer-Brandl, O. Schwardt, S. Kelm, and B. Ernst (2012): From a library of MAG antagonists to nanomolar CD22 ligands. Chem. Med. Chem. 7,134-143, DOI: 10.1002/cmdc.201100407.

H. Koliwer-Brandl, T.T. Gbem, M. Waespy, O. Reichert, P. Mandel, E. Drebitz, F. Dietz, S. Kelm (2011): Biochemical characterization of trans-sialidase TS1 variants from Trypanosoma congolense, BMC Biochemistry 12, 39, DOI: 10.1186/1471-2091-12-39.

C. Jones, J. Denecke, R. Sträter, T. Stölting, Y. Schunicht, D. Zeuschner, J. Klumperman, D. J. Lefeber, O. Spelten, A. Zarbock, S. Kelm, K. Strenge, S. M. Haslam, K. Lühn, D. Stahl, L. Gentile, T. Schreiter, P. Hilgard, A. G. Beck-Sickinger, T. Marquardt, and Martin K. Wild (2011): A novel type of macrothrombocytopenia associated with a defect in α2,3-sialylation, Am. J. Pathol. 179, 1969-1977, DOI: 10.1016/j.ajpath.2011.06.012

M. Nullmeier, H. Koliwer-Brandl, S. Kelm, P. Zägel, K.-W. Koch, I. Brand (2011): Impact of strong and weak lipid–protein interactions on the structure of a lipid bilayer on a gold electrode surface, Chem. Phys. 12, 1066-1079, DOI: 10.1002/cphc.201100036.

H. Koliwer-Brandl, N. Siegert, K. Umnus, A. Kelm, A. Tolkach, U. Kulozik, J- Kuballa, S. Cartellieri, S. Kelm (2011): Lectin inhibition assays for the analysis of bioactive milk sialoglycoconjugates, International Dairy Journal 21, 413-420, DOI: 10.1016/j.idairyj.2011.01.005.

 

K. Thakar, T. Kröcher, So. Savant, D. Gollnast, S. Kelm, F. Dietz (2010): Secretion of hepatoma-derived growth factor is regulated by N-terminal processing, Biol. Chem. 391, 1401-1410, DOI: 10.1515/BC.2010.147.

M. M. Schmidt, H. Greb, H. Koliwer-Brandl, S. Kelm, R. Dringen (2010): 2-Deoxyribose deprives cultured astrocytes of their glutathione, Neurochem. Res. 35, 1848–1856, DOI: 10.1007/s11064-010-0251-y.

O. Schwardt, H. Koliwer-Brandl, R. Zimmerli, S. Mesch, G. Rossato, M. Spreafico, A. Vedani, S. Kelm, B. Ernst (2010): Design, synthesis, biological evaluation, and modeling of a non-carbohydrate antagonist of the myelin-associated glycoprotein, Bioorg. Med. Chem. 18, 7239-7251, DOI: 10.1016/j.bmc.2010.08.027

S. V. Shelke, B. Cutting, X. H. Jiang, H. Koliwer-Brandl, D. S. Strasser, O. Schwardt, S. Kelm, B. Ernst (2010): A Fragment-based in situ combinatorial approach to identify high-affinity ligands for unknown binding sites, Angew. Chem. Int. Ed. Engl. 49, 5721-5725, DOI: 10.1002/anie.200907254.

M. Nullmeier, H. Koliwer-Brandl, S. Kelm, I. Brand (2010): Interaction of siglec protein with glycolipids in a lipid bilayer deposited on a gold electrode surface, J. Electroanalytical Chem. 649, 177–188, DOI: 10.1016/j.jelechem.2010.03.033

S. Mesch, K. Lemme, H. Koliwer-Brandl, D. S. Strasser, O. Schwardt, S. Kelm, B. Ernst, (2010): Kinetic and thermodynamic properties of MAG antagonists, Carbohydr. Res. 345, 1348-1359, DOI: 10.1016/j.carres.2010.03.010.

S. Mesch, D. Moser, D. Strasser, A. Kelm, B. Cutting, G. Rossato, A. Vedani, H. Koliwer-Brandl, M. Wittwer, S. Rabbani, O. Schwardt, S. Kelm, B. Ernst, (2010): Low molecular weight antagonists of the myelin-associated glycoprotein: Synthesis, docking and biological evaluation, J. Med. Chem. 53, 1597-1615, DOI: 10.1021/jm901517k .

O. Schwardt, H. Gäthje, A. Vedani, S. Mesch, G. P. Gao, M. Spreafico, J. von Orelli, S. Kelm, B. Ernst (2009): Examination of the biological role of the α(2→6)-linked sialic acid in gangliosides binding to the myelin-associated glycoprotein (MAG), J. Med. Chem. 52, 989-1004, DOI: 10.1021/jm801058n.

 

S. Y. Shin, H. Gäthje, O. Schwardt, G. P. Gao, B. Ernst, S. Kelm, B. Meyer (2008): Binding epitopes of gangliosides to their neuronal receptor, myelin-associated glycoprotein, from saturation transfer difference NMR, Chembiochem. 15, 2946-2949, DOI: 10.1002/cbic.200800485.

A. Bhunia, O. Schwardt, H. Gäthje, G. P. Gao, S. Kelm, A. J. Benie, M. Hricovini, T. Peters, B. Ernst (2008): Consistent bioactive conformation of the Neu5Aca(2-3)Gal epitope upon lectin binding, Chembiochem. 15, 2941-2945, DOI: 10.1002/cbic.200800458.

H. H. Abdu-Allah, T. Tamanaka,J. Yu, L. Zhuoyuan, M. Sadagopan, T. Adachi, T. Tsubata, S. Kelm, H. Ishida, M. Kiso (2008): Design, synthesis, and structure-affinity relationships of novel series of sialosides as CD22-specific inhibitors, J. Med. Chem. 13, 6665-6681, DOI: 10.1021/jm8000696.

K. Thakar, R. Niedenthal, E. Okaz, S. Franken, A. Jakobs, S. Gupta, S. Kelm, F. Dietz (2008): SUMOylation of the hepatoma-derived growth factor negatively influences its binding to chromatin, FEBS J. 275, 1411-1426, DOI: 10.1111/j.1742-4658.2008.06303.x.

F. Lehmann, S. Kelm, F. Dietz, M. von Itzstein, J. Tiralongo (2008): The evolution of galactose α(2→3)-sialyltransferase: Ciona intestinalis ST3GAL I/II and Takifugu rubripes ST3GAL II sialylate Galβ1,3GalNAc structures on glycoproteins but not glycolipids, Glycoconj. J. 25, 323-334, DOI: 10.1007/s10719-007-9078-4

G. Gao, M. Smiesko, O. Schwardt, H. Gäthje, S. Kelm, A. Vedani, B. Ernst (2007): Mimetics of the tri- and tetrasaccharide epitope of GQ1bα as myelin-associated glycoprotein (MAG) ligands, Bioorg. Med. Chem. 15, 7459-69, DOI: 10.1016/j.bmc.2007.07.033.

B. Cutting, S. V. Shelke, Z. Dragic, B. Wagner, H. Gäthje, S. Kelm, B. Ernst (2007): Sensitivity enhancement in saturation transfer difference (STD) experiments through optimized excitation schemes, Magn. Reson. Chem. 45, 720-724, DOI: 10.1002/mrc.2033.

S. V. Shelke, G. P. Gao, S. Mesch, H. Gäthje, S. Kelm, O. Schwardt, B. Ernst (2007): Synthesis of sialic acid derivatives as ligands for the myelin-associated glycoprotein (MAG), Bioorg. Med. Chem. 15, 4951-4965, DOI: 10.1016/j.bmc.2007.04.038.

N. R. Zaccai, A. P. May, R. C. Robinson, L. D. Burtnick, P.R. Crocker, R. Brossmer, S. Kelm, E. Y. Jones (2007): Crystallographic and in silico analysis of the sialoside binding characteristics of the Siglec Sialoadhesin, J. Mol. Biol. 365, 1469-1479, DOI: 10.1016/j.jmb.2006.10.084.