Course Catalog

Study Program WiSe 2024/2025

Epidemiologie, M.Sc.

1. Semester (BPO 2023)

FAFEpi: Forschungs- und Anwendungsfelder der Epidemiologie (Modulverantwortlicher: Prof. Dr. Hajo Zeeb)

1 Vorlesung, 1 Seminar
6CP
Course numberTitle of eventLecturer
11-PH-MA-FAFEpi-1Geschichte, Konzepte und Public Health - Einbettung der Epidemiologie

Lecture (Teaching)

Dates:
weekly (starts in week: 1) Mon. 12:00 - 14:00 Achterstr. 30 2.690 (2 Teaching hours per week)

In dieser Veranstaltung, die als ein Teil der vertiefenden Einführung in die Epidemiologie gedacht ist, geht es um Geschichte, Konzepte und aktuelle Themen der Epidemiologie. Dabei wird ein Fokus auf die angewandte Epidemiologie im Kontext von Public Health gelegt, also wie trägt die Epidemiologie zur Fortentwicklung von Public Health bei? Dabei wird auch eine historische Perspektive eingenommen, d-h. gemeinsam werden auch zentrale Studien und methodische Entwicklungen erörtert. Unterschiedliche epidemiologische Ansätze (z.B. Risikofaktorenepidemiologie, ökosoziale Epidemiologie) werden kontrastiert und in der Diskussion studentischer Beiträge genau charakterisiert.

Das Seminar am Montag wird durch die Vorlesungsreihe am Donnerstag 16:00 ergänzt, bei dem sich die verschiedenen Lehrenden im Bereich Epidemiologie mit ihren eigenen Forschungsbereichen und aktuellen Themen vorstellen.

Prof. Dr. Hajo Zeeb, M. Sc
Tilman Brand
11-PH-MA-FAFEpi-2Ringvorlesung: Aktuelle Forschungsthemen

Lecture (Teaching)

Dates:
weekly (starts in week: 1) Thu. 16:15 - 17:00 GW1 B0080 (1 Teaching hours per week)
Prof. Dr. Hajo Zeeb, M. Sc
Prof. Dr. Gabriele Dagmar Bolte

EpiSkills: Skills Lab Epidemiologie (Modulverantwortliche: Prof. Dr. Krasimira Aleksandrova)

2 Seminare, 1 Übung
9CP
Course numberTitle of eventLecturer
11-PH-MA-EpiSkills-1Introduction to literature search and scientific writing (in English)
Einführung in die Literaturrecherche und das wissenschaftliche Schreiben

Seminar (Teaching)

Dates:
weekly (starts in week: 1) Tue. 10:00 - 12:00 Achterstr. 30 1.550 (2 Teaching hours per week)

Seminar: Introduction to literature search and scientific writing
MSc Epidemiology, Module EpiSkills: Skills Lab Epidemiology
Module organiser: Prof. Dr. Krasimira Aleksandrova
Semester: Winter 2024/2025

Lecturer (seminar, exercises): Prof. Dr. Krasimira Aleksandrova, PhD, MPH
Phone number: +49 421 218 56 816
Email: aleksandrova@leibniz-bips.de

Course prerequisites
N/A

Overview
This seminar will introduce the students to the scientific concepts and methods of epidemiological research from a practical perspective. It is aimed at providing basic skills for writing epidemiological research papers and searching and evaluating the scientific literature. The students will get acquainted with the current developments and areas of work in epidemiology and the needed skills in writing high quality epidemiological research works. They will learn how to formulate an adequate and scientifically relevant research questions and the steps in conducting systematic reviews and evidence synthesis of various epidemiological studies in the context of evidence-based health research. They will also learn about the various guidelines for conducting and reporting epidemiological studies and systematic reviews and how to use them to improve quality of their work. The seminars will be illustrated with examples taken from the contemporary scientific literature. There will be thorough discussions on how to properly write and interpret epidemiological papers taking overall research context into account. Ultimately, the students will gain knowledge about the main skills needed and the prospects for professional career development in the field of epidemiology. They will get acquainted with the various career opportunities and will learn about the epidemiological professional organisations and networks in Germany and internationally.

At the end of this seminar, the students will be able to:
- Formulate research questions in epidemiology
- Know how to use the PICOT (population, intervention, comparison, outcome and timeframe) and FINER (feasible, interesting, novel, ethical, relevant) formats for defining research questions
- Know the principles of writing research articles reporting epidemiological findings
- Plan the required steps in conducting and interpreting results of systematic reviews in epidemiology and health research
- Understand the broader prospects for career development in the field of epidemiology.

Course Materials
Materials and suggested readings will be provided during the seminar.

Course requirements
Group work and in-class discussions: Students will work on specific research topics and practice how to turn research ideas into research questions and how to plan manuscript writing. They will be asked to read various articles that provide examples of various epidemiological papers. The students will briefly present the studies using a list of predefined questions. They should learn to address the appropriateness of the research question, the methodological aspects related to the used study design, and the description of data analysis and results interpretation.

Final project. Planning a manuscript addressing particular research question in epidemiology
Using the guidelines of the preselected journals, they will plan writing a manuscript where they should clearly present the research question and identify gaps and existing inconsistencies that need to be addressed. The students should show that they can clearly describe the research question, provide justification and supporting literature; critically appraise quality of the study designs and apply relevant guidelines, as well as demonstrate critical thinking. The students will receive also suggested literature that they can use and specific instructions on how to structure their final project report.

Final presentation:
Each student will be given the opportunity to present their final work as a 15 minute presentation + 5-10 min discussion and get feedback on their project.

Prof. Dr. Krasimira Aleksandrova
11-PH-MA-EpiSkills-2Übungen zur Literaturrecherche und wissenschaftlichem Arbeiten

Exercises (Teaching)

Dates:
weekly (starts in week: 1) Tue. 12:00 - 13:00 Achterstr. 30 1.550 (1 Teaching hours per week)
Prof. Dr. Krasimira Aleksandrova
11-PH-MA-EpiSkills-3Ethik und Epidemiologie

Seminar (Teaching)

Dates:
weekly (starts in week: 1) Mon. 10:00 - 12:00 GRA2 0140 (2 Teaching hours per week)

Die Public Health Ethik ist in Deutschland ein sehr junges Fach. Public Health Ethiker*innen befassen sich systematisch mit der Bestimmung, Bewertung und Priorisierung möglicher Vorgehensweisen im Bereich Public Health. Die Basis bilden ethische Grundsätze, Prinzipien und Werte; aber auch die Überzeugungen von Interessengruppen. Public Health-Ethiker*innen arbeiten interdisziplinär, um Lösungen für ethische Probleme in Forschung und Praxis zu entwickeln.
Ausgehend von aktuellen Entwicklungen in der Public Health Ethik gibt das Seminar einen übergreifenden Einblick in den Zusammenhang von Ethik und Epidemiologie. Schwerpunkte sind:
• Unterschied zwischen Moral und Ethik
• zentrale ethische Theorien
• Aufbau einer ethischen Argumentation
• wichtige ethische Prinzipien (wie Autonomie, Nicht-Schaden, Gerechtigkeit, Vulnerabilität, Solidarität, Vertrauen)
• exemplarische Themenfelder von Ethik und Epidemiologie
• Ethik als Praxisfeld (z.B. in Ethikkommissionen, öffentlichen Gremien und Institutionen) mit besonderem Fokus auf Forschungsethik und Datenschutz
Die Prüfungsleistung ist entweder ein Referat oder eine Hausarbeit.

Zur ersten Blocksitzung werden Texte (englisch und deutsch) bereitgestellt, die gemeinsam diskutiert werden. In der zweiten und dritten Blocksitzung können die Studierenden Referate zu selbstgewählten Themen aus dem Bereich Ethik und Epidemiologie halten.

PD Dr. Solveig Lena Hansen

EpiStat1: Epidemiologie und statistische Anwendungen (Modulverantwortliche: Dr. Stefanie Dreger)

2 Vorlesungen, Unterstützende Tutorien
9CP
Course numberTitle of eventLecturer
11-PH-MA-EpiStat1-1Epidemiology

Lecture (Teaching)

Dates:
weekly (starts in week: 1) Thu. 10:00 - 12:00 GW2 B1410 (2 Teaching hours per week)
Dr. Stefanie Dreger
11-PH-MA-EpiStat1-2aÜbung 1 Epidemiologie

Exercises (Teaching)

Dates:
weekly (starts in week: 1) Tue. 16:00 - 18:00 Achterstr. 30 1.550 (2 Teaching hours per week)
Dr. rer. nat. Oliver Scholle
11-PH-MA-EpiStat1-2bÜbung 2 Epidemiologie

Exercises (Teaching)

Dates:
weekly (starts in week: 1) Fri. 12:00 - 14:00 GRA2A H 0100 GRA4 A0110 (2 Teaching hours per week)
Dr. Hannah Jilani
11-PH-MA-EpiStat1-3Statistik

Lecture (Teaching)

Dates:
weekly (starts in week: 1) Fri. 08:00 - 10:00 GRA2A H 0100 (2 Teaching hours per week)
Dr. Martin Scharpenberg
11-PH-MA-EpiStat1-4aÜbung 1 Statistik

Exercises (Teaching)

Dates:
weekly (starts in week: 1) Fri. 10:00 - 12:00 GRA2A H 0100 (2 Teaching hours per week)
Dr. Martin Scharpenberg
Dr. Klaus Telkmann
11-PH-MA-EpiStat1-4bÜbung 2 Statistik

Exercises (Teaching)

Dates:
weekly (starts in week: 1) Tue. 08:00 - 10:00 UNICOM 3.0220 Seminarraum 4 (2 Teaching hours per week)
Dr. Martin Scharpenberg
Dr. Rolf Müller

EpiProjekt1: Projektstudium Epidemiologische Forschung - Grundlagen und Fragestellung (Modulverantwortliche: PD Dr. Karin Bammann)

2 Seminare, Tutorium
6CP
Course numberTitle of eventLecturer
11-PH-MA-EpiProjekt1-1Epidemiologische Forschung - Grundlagen und Fragestellung

Seminar (Teaching)

Dates:
weekly (starts in week: 1) Thu. 08:00 - 10:00 External location: Online (2 Teaching hours per week)
Prof. Dr. Karin Bammann
Dr. Stefanie Dreger
11-PH-MA-EpiProjekt1-2Epidemiologische Forschung - Grundlagen und Fragestellung

Seminar (Teaching)

Dates:
weekly (starts in week: 1) Thu. 14:00 - 16:00 GRA2 0080 (2 Teaching hours per week)
Prof. Dr. Karin Bammann
Dr. Stefanie Dreger
11-PH-MA-EpiProjekt1-3SAS-Kurs

Seminar (Teaching)

Dates:
weekly (starts in week: 1) Mon. 14:00 - 16:00 Cog 0320 (2 Teaching hours per week)
Jonas Czwikla
Dr. Klaus Telkmann
11-PH-MA-EpiProjekt1-4Übung zum SAS-Kurs

Exercises (Teaching)

Dates:
weekly (starts in week: 1) Mon. 16:00 - 18:00 Cog 0320 (2 Teaching hours per week)
Dr. Klaus Telkmann

3. Semester (BPO 2023)

EpiStat3 Fortgeschrittene epidemiologische und statistische Methoden (Modulverantwortliche: Prof. Dr. Karin Bammann

Course numberTitle of eventLecturer
11-PH-MA-EpiStat3-1Fortgeschrittene epidemiologische und statistische Methoden

Seminar (Teaching)

Dates:
weekly (starts in week: 1) Mon. 14:00 - 18:00 GRA2 0180 (4 Teaching hours per week)
Prof. Dr. Karin Bammann
Dr. Klaus Telkmann

EpiProjekt3 Projektstudium Epidemiologische Forschung - Datenanalyse und Interpretation (Modulverantwortliche: Prof. Dr. Gabriele Bolte)

Course numberTitle of eventLecturer
11-PH-MA-EpiProjekt3-1Projektstudium Epidemiologische Forschung - Datenanalyse und Interpretation

Seminar (Teaching)

Dates:
weekly (starts in week: 1) Thu. 10:00 - 14:00 GRA2 0180 (4 Teaching hours per week)
Prof. Dr. Gabriele Dagmar Bolte
Prof. Dr. Karin Bammann

MonSurGBE Monitoring, Surveillance und Gesundheitsberichterstattung (Modulverantwortlicher: Prof. Dr. Hajo Zeeb)

Course numberTitle of eventLecturer
11-PH-MA-MonSurGBE-1Monitoring, Surveillance und Gesundheitsberichterstattung - Grundlagen und Konzepte

Seminar (Teaching)

Dates:
weekly (starts in week: 1) Thu. 14:00 - 16:00 Achterstr. 30 2.690 (2 Teaching hours per week)

Dieses Seminar konzentriert sich auf die wichtigen epidemiologischen Aufgaben des Monitorings und der Surveillance und deren Bedeutung für die Gesundheitsberichterstattung. Prinzipien der GBE auf unterschiedlichen Ebenen (regional bis international) werden beschrieben und diskutiert, dabei ist ein wichtiger Punkt das Verständnis von Indikatoren bzw. dem Vorgehen bei der Indikatorenentwicklung. Ein Fokus liegt auf den Konzepten und Ansätze des Monitorings von umwelt- und arbeitsweltbezogenen Expositionen einschließlich von Methoden der Expositionsabschätzung. Querbezüge zwischen Monitoring und Surveillance werden anhand von Beispielen erarbeitet, dabei wird als weiterer wichtiger Bereich die infektionsepidemiologische Surveillance adressiert. In Blockseminar- Anteilen werden u.a. eigene Gesundheitsberichte erstellt bzw. vorhandene Gesundheitsberichte ergänzt und erweitert.

Prof. Dr. Hajo Zeeb, M. Sc
Prof. Dr. Gabriele Dagmar Bolte
11-PH-MA-MonSurGBE-2Monitoring, Surveillance und Gesundheitsberichterstattung - Übung

Exercises (Teaching)

Additional dates:
Fri. 29.11.24 09:00 - 14:30 Achterstr. 30 2.690
Fri. 10.01.25 09:00 - 14:30 Achterstr. 30 2.690
Prof. Dr. Hajo Zeeb, M. Sc
Prof. Dr. Gabriele Dagmar Bolte

SozialEpi Sozialepidemiologie (Modulverantwortliche: Prof. Dr. Gabriele Bolte)

Course numberTitle of eventLecturer
11-PH-MA-SozialEpi-1Grundlagen und aktuelle Forschung in der Sozialepidemiologie

Seminar (Teaching)

Dates:
weekly (starts in week: 1) Mon. 10:00 - 12:00 GRA2 0080 (2 Teaching hours per week)
Prof. Dr. Gabriele Dagmar Bolte
Gesa Czwikla
Sophie Horstmann
11-PH-MA-SozialEpi-2Studiendesign und Datenanalyse in der Sozialepidemiologie (Zeit nach Vereinbarung)

Exercises (Teaching)

Zeit nach Vereinbarung
Die Lehrenden vereinbaren mit Ihnen mehrere Austausch- und Beratungstermine.
(online oder Präsenz)

Prof. Dr. Gabriele Dagmar Bolte
Gesa Czwikla
Sophie Horstmann

MolEpi Molecular and genetic epidemiology (Modulverantwortliche: Prof. Dr. Krasimira Aleksandrova)

Course numberTitle of eventLecturer
11-PH-MA-MolEpi-1Seminar + Übung: Molecular and genetic epidemiology (in English)

Seminar (Teaching)

Additional dates:
Fri. 18.10.24 10:00 - 15:00 Achterstr. 30 0.490
Fri. 25.10.24 10:00 - 15:00 Achterstr. 30 0.490
Fri. 01.11.24 10:00 - 15:00 Achterstr. 30 0.490
Fri. 08.11.24 10:00 - 15:00 Achterstr. 30 0.490
Fri. 15.11.24 10:00 - 15:00 Achterstr. 30 0.490
Fri. 22.11.24 10:00 - 15:00 Achterstr. 30 0.490
Fri. 29.11.24 10:00 - 15:00 Achterstr. 30 0.490

MSc Epidemiology
Modul 11-PH-MA-MolEpi: Molecular and Genetic Epidemiology
Modul organiser: Prof. Dr. Krasimira Aleksandrova
Semester: Winter 2024/2025

Course lecturer: Prof. Dr. Krasimira Aleksandrova, PhD, MPH
Phone number: +49 421 218 56 816
Email: aleksandrova@leibniz-bips.de

Course prerequisites
Knowledge of basic concepts in epidemiology and study designs.

Course Overview
This course will introduce the students to the basic principles and practices in molecular epidemiology as a rapidly developing field during the last decades driven by the novel biomedical discoveries at molecular and genetic level. The course will start with providing an overview of the contextual framework for establishing the molecular epidemiology as a new branch in epidemiology including the recent developments in the biomedical field. Throughout the course, the students will gain understanding on various practical aspects related to the use of biomarkers in epidemiological research. These include considerations of the type of biomarkers, the biosample collection, processing and storage, biomarker measurements, principles of quality control for laboratory assays, measurement error, validity and reproducibility of biomarker data. The students will get to know specific study designs that allow integration and analysis of biomarkers in epidemiologic research, i.e. nested case-control and case-cohort studies. They will learn to appraise issues in epidemiologic study design and analysis, incl. potential uses and limitations of biomarkers. The students will be also exposed to numerous examples of the application of biomarkers to the study of major chronic diseases. They will learn how to biomarkers are applied in different epidemiological research contexts, such as causal inference (i.e. using mediation and Mendelian randomisation) and risk prediction analyses (i.e. precision prevention and biomarker-based risk stratification). In addition, they will learn about specific applications of molecular and genetic biomarkers in various population groups. A specific emphasis will be put on the ethical and legal aspects in biomarker research. The course will conclude with discussing the recent developments in establishing large biobanks, the shifting from human genome to human exposome research and the increasing use of biomarkers measured using novel biotechnological platforms, incl. metabolomics, transcriptomics and proteomics. The lecture topics will be organised to combine theoretical and practical aspects of molecular epidemiology and will include multiple class exercises and discussions of specific research examples involving biomarkers.

Course Objectives

This course is aimed to provide a background for understanding the basic principles in molecular epidemiology designs, methods, analysis and interpretation. Upon successful completion of the course, students should be able to:
• Know the contextual framework, the principles and concepts of molecular epidemiology and the application of biomarkers in epidemiologic studies, including their strengths and limitations;
• Describe major challenges in collecting, storing and processing various biological samples for human population studies, as well as the ethical and legal considerations;
• Formulate a research question and prepare a study and analysis plan employing study designs in molecular and genetic epidemiology;
• Critically appraise research reporting data from molecular and genetic epidemiological studies from etiology to risk prediction;
• Know the new developments in the field of molecular epidemiology and the increasing use of large biobanks and ‘-omics’ technologies.

Course Materials
Recommended:
Molecular Epidemiology of Chronic Diseases by Chris Wild, Paolo Vineis, and Seymour Garte. Hoboken, NJ: John Wiley & Sons Inc., 2008.
Further materials and suggested readings will be provided during the course.

Course requirements
In-class paper discussions: Students will be asked to read an article that provides an example of uses of biomarkers to investigate associations of interest. The students will briefly present the study using a list of predefined questions. They should learn to address the appropriateness the research question, the methodological aspects related to the used study design, biomarker information and data analysis/interpretation.

Final project. Students will have an opportunity to choose from two possible formats for preparing a final project. The students will receive also suggested literature that they can use and specific instructions on how to structure their final project report.
Option 1: A research proposal for a molecular epidemiology study.
The students should develop a short project proposal to address a research question in the field of molecular epidemiology. It should describe the research background, the specific hypothesis and research objectives, the study design (study population, exclusion/inclusion criteria; sample collection; biomarker measurement), planned statistical analyses and potential study limitations. The students should demonstrate that they can clearly describe the research question, provide justification and supporting literature; make a proper study design choice and demonstrate critical thinking.
Option 2: Literature review on the use of a biomarker(s) for addressing a particular research question
The students will be offered specific topics and can make a choice for conducting a literature review addressing a specific research question. Using the guidelines of the preselected journals, they will plan and conduct a literature review in which they should clearly present the research question and identify gaps and existing inconsistencies that need to be addressed by the review. They will suggest a strategy for collecting the literature and appropriate methods and data presentation. The students should show that they can clearly describe the research question, provide justification and supporting literature; critically appraise used study designs and demonstrate critical thinking.

Final presentation:
Each student will be given the opportunity to present their final work as a 15 minute presentation + 5-10 min discussion and receive feedback.

Prof. Dr. Krasimira Aleksandrova

ab 5. Semester (ab WiSe 2016/2017)

9-E Begleitseminar zur Masterarbeit

Modulverantwortliche: Prof. Dr. Gabriele Bolte

Pflichtmodul, 3 CP
Course numberTitle of eventLecturer
11-PH-MA-M9-E-1Begleitseminar zur Masterarbeit (Online-Seminar)

Seminar (Teaching)

Dates:
weekly (starts in week: 1) Fri. 10:00 - 12:00 Online (2 Teaching hours per week)
Dr. Stefanie Dreger

Ergänzende Veranstaltungen

Course numberTitle of eventLecturer
11-PH-MA-E-ZusatzQuantitative Forschungswerkstatt

Research group (Teaching)

Additional dates:
Wed. 24.01.18 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 28.02.18 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 28.03.18 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 25.04.18 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 23.05.18 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 27.06.18 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 25.07.18 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 22.08.18 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 26.09.18 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 24.10.18 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 28.11.18 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 23.01.19 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 27.02.19 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 27.03.19 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 24.04.19 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 22.05.19 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)
Wed. 26.06.19 10:00 - 11:30 GRA4 A1010/1020 (EEG-Labor)

Termin: jeden vierten Mittwoch im Monat

Dr. Stefanie Dreger