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Dr. Lena Hauberg-Lotte

Dr. Lena Hauberg-Lotte

Research associate

Project manager
Deep Learning und Digitale Pathologie

Bibliothekstraße 5
28359 Bremen

Office: MZH 2200
Phone: +49 421 218-63807
E-Mail: haubergprotect me ?!uni-bremenprotect me ?!.de

Research areas

  • Digital pathology
  • MALDI imaging

Projects

  • DIAMANT - Digital image analysis and imaging mass spectrometry for differentiation of non-small cell lung cancer
  • MALDISTAR - Study on quality assessment, standardization and reproducibility of MALDI imaging mass spectrometry data
  • SPAplus - Small Data problems in digital pathology

 

Journal articles

Le’Clerc Arrastia J, Heilenkötter N, Otero Baguer D, Hauberg-Lotte L, Boskamp T, Hetzer S, Duschner N, Schaller J, Maass P. Deeply Supervised UNet for Semantic Segmentation to Assist Dermatopathological Assessment of Basal Cell Carcinoma. Journal of Imaging. 2021; 7(4):71. DOI: https://doi.org/10.3390/jimaging7040071

T. Boskamp, D. Lachmund, R. Casadonte, L. Hauberg-Lotte, J. H. Kobarg, J. Kriegsmann, P. Maaß.
Using the chemical noise background in MALDI mass spectrometry imaging for mass alignment and calibration.
Analytical Chemistry, 92(1):1301-1308, 2020.
DOI: 10.1021/acs.analchem.9b04473
online unter: https://doi.org/10.1021/acs.analchem.9b04473

A. Ardestani, S. Li, K. Annamalai, B. Lupse, S. Geravandi, A. Dobrowolski, S. Yu, S. Zhu, T. D. Baguley, M. Surakattula, J. Oetjen, L. Hauberg-Lotte, R. Herranz, S. Awal, D. Altenhofen, V. Nguyen-Tran, S. Joseph, P. G. Schultz, A. K. Chatterjee, N. Rogers, M. S. Tremblay, W. Shen, K. Maedler.
Neratinib protects pancreatic beta cells in diabetes.
Nature Communications, 10(5015), 2019.
DOI: 10.1038/s41467-019-12880-5

J. Quanico, L. Hauberg-Lotte, S. Devaux, Z. Laouby, C. Mériaux, A. Raffo-Romero, M. Rose, L. . Westerheide, J. Vehmeyer, F. Rodet, P. Maaß, D. Cizkova, N. Zilka, V. Cubinkova, I. Fournier, M. Salzet.
3D MALDI mass spectrometry imaging reveals specific localization of long-chain acylcarnitines within a 10-day time window of spinal cord injury.
Scientific Reports, 8(16083), 2018.
DOI: 10.1038/s41598-018-34518-0

Y. Cordero Hernandez, T. Boskamp, R. Casadonte, L. Hauberg-Lotte, J. Oetjen, D. Lachmund, A. Peter, D. Trede, K. Kriegsmann, M. Kriegsmann, J. Kriegsmann, P. Maaß.
Targeted Feature Extraction in MALDI Mass Spectrometry Imaging to Discriminate Proteomic Profiles of Breast and Ovarian Cancer.
Proteomics - Clinical Applications, 1700168 , Wiley, 2018.
DOI: 10.1002/prca.201700168

S. Devaux, D. Cizkova, J. Quanico, J. Franck, S. Nataf, L. Pays, L. Hauberg-Lotte, P. Maaß, J. H. Kobarg, F. Kobeissy, C. Mériaux, M. Wisztorski, L. Slovinska, J. Blasko, V. Cigankova, I. Fournier, M. Salzet.
Proteomic Analysis of the Spatio-temporal Based Molecular Kinetics of Acute Spinal Cord Injury Identifies a Time- and Segment-specific Window for Effectife Tissue Repair.
Molecular & Cellular Proteomics, 15:2641-2670, 2016.
DOI: 10.1074/mcp.M115.057794

J. Oetjen, K. Veselkov, J. Watrous, J. McKenzie, M. Becker, L. Hauberg-Lotte, J. H. Kobarg, A. K. Mróz, N. Strittmatter, F. Hoffmann, D. Trede, A. Palmer, S. Schiffler, K. Steinhorst, M. Aichler, R. Goldin, O. Guntinas-Lichius, F. von Eggeling, H. Thiele, K. Mädler, A. Walch, P. Maaß, P. C. Dorrestein, Z. Takats, F. Alexandrov.
Benchmark datasets for 3D MALDI- and DESI-imaging mass spectrometry.
GigaScience, 4, 2015.
DOI: 10.1186/s13742-015-0059-4

G. Ernst, O. Guntinas-Lichius, L. Hauberg-Lotte, D. Trede, M. Becker, F. Alexandrov, F. von Eggeling.
Histomolecular interpretation of pleomorphic adenomas of the salivary gland by matrix-assisted laser desorption ionization imaging and spatial segmentation.
Head & Neck, 37(7), 2014.
DOI: 10.1002/hed.23713

 

Preprints

C. Etmann, M. Schmidt, J. Behrmann, T. Boskamp, L. Hauberg-Lotte, A. Peter, R. Casadonte, J. Kriegsmann, P. Maaß.
Deep Relevance Regularization: Interpretable and Robust Tumor Typing of Imaging Mass Spectrometry Data.
Zur Veröffentlichung eingereicht.
online unter: https://arxiv.org/abs/1912.05459

 

 

 

since 2013

Research Assistant at the Center for Industrial Mathematics, University of Bremen 

2014 - 2016

Project Manager Research Funding, SCiLS Research, Steinbeis Innovation gGmbH 

 2012 

Research Associate, MALDI Imaging Lab, University of Bremen 

2010

Promotion zum Dr. rer. nat, University of Bremen, Thema: "Molekulare Charakterisierung des neuartigen Quorum-Sensing-Systems des Gras-Endophyten Azoarcus sp. BH72" 

2006 - 2010

Research Associate, Molecular Plant-Bacteria Interactions, University of Bremen, Germany. 

2006

Diplom in Microbiology 

2000 - 2006

Study of Biology, University of Bremen (Microbiology, Molecular and Cell Biology, Botany)