60 https://www.uni-bremen.de/islets/islet-research Islet Research de Universität Bremen Wed, 20 May 2026 22:31:56 +0200 Wed, 20 May 2026 22:31:56 +0200 Universität Bremen content-138665 Thu, 16 Feb 2023 11:29:56 +0100 https://www.uni-bremen.de/islets/islet-research#c138665 <p><strong>The essential points toward the investigations of Hippo functions in the beta-cell:</strong></p> <p>• The <a class="externalLink" href="https://academic.oup.com/edrv/article/39/1/21/4555312?login=false" target="_blank" title="Öffnet externen Link in neuem Fenster">Hippo</a> pathway regulates pancreas development including pancreatic progenitor cell proliferation, cell specification and differentiation as well as growth and cellular plasticity of the pancreas.</p> <p><a class="externalLink" href="https://www.tandfonline.com/doi/full/10.1080/15548627.2021.1972404?tab=permissions&scroll=top" target="_blank" title="Öffnet externen Link in neuem Fenster">• Hippo signaling is very complex and dynamic and interacts and crosstalks with many other signaling pathways, which regulate beta-cell survival, such as the intrinsic apoptotic pathway, mTOR, PI3K-AKT and MAPK-JNK to respond to exogenous and endogenous stimuli. </a></p> <p>• Hippo pathway components control various aspects of β-cell homeostasis including beta-cell function, survival and proliferation.</p> <p>• The Hippo terminal effector YAP is not expressed in mature endocrine islet cells and its reconstitution promotes β-cell proliferation and survival.</p> <p>• Targeting Hippo pathway could be an essential therapeutic approach for β-cell regenerative therapy.</p> <p><a class="externalLink" href="https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(18)30089-4" target="_blank" title="Öffnet externen Link in neuem Fenster">Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism. Trends </a><strong>Endocrinol</strong> <strong>Metab</strong><strong>. 2018 </strong></p> Content