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Publications

Selected publications (since 2001)

Wei He, Osmond Rebello, Rocco Savino, Rosa Terracciano, Carole Schuster-Klein, Beatrice Guardiola and Kathrin Maedler. TLR4 triggered complex inflammation in human pancreatic islets.  BBA - Molecular Basis of Disease. 2018 in Press.
Ardestani A, Maedler K. mTORC1 and IRS1: Another Deadly Kiss.Trends Endocrinol Metab. 2018.
Gorrepati KDD, He W, Lupse B, Yuan T, Maedler K, Ardestani A. An SCFFBXO28 E3 Ligase Protects Pancreatic β-Cells from Apoptosis. Int J Mol Sci. 2018 Mar 24;19(4). pii: E975.
Ardestani A, Lupse B, Maedler K. Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism. Trends Endocrinol Metab. 2018 May 5. pii: S1043-2760(18)30089-4
Ting Yuan, Blaz Lupse, Kathrin Maedler & Amin Ardestani. mTORC2 Signaling: A Path for Pancreatic β-Cell’s growth and function. J Mol Biol. 2018 Mar 30;430(7):904-918.
Kanaka Durga Devi Gorrepati, Blaz Lupse, Karthika Annamalai, Ting Yuan, Kathrin Maedler*and Amin Ardestani* (senior authors; equal contribution). Loss of deubiquitinase USP1 blocks pancreatic β-cell apoptosis by inhibiting DNA damage response. iScience 2018
He W, Yuan T, Choezom D, Hunkler H, Annamalai K, Lupse B, Maedler K. Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4.Sci Rep. 2018 Feb 9;8(1):2767. doi: 10.1038/s41598-018-20909-w.
Ardestani, A. Lupse, B. Yoshiaki, K., Leibowitz,G. & Maedler, K. mTORC1 Signaling: A Double Edge Sword in Diabetic β-cells. Cell Metab. 2018 Feb 6;27(2):314-331.
Ardestani, A. & Maedler, K. The Hippo signaling pathway in pancreatic β-cells: functions and regulations, Endocr Rev. 2017 Oct 18. doi: 10.1210/er.2017-00167.
Maedler, K. & Ardestani, A. mTORC in beta cells: more Than Only Recognizing Comestibles, JCB 216,7, 1883-1885 (2017)
Yuan, T., Maedler, K. & Ardestani, A. Pancreatic β-cell rescue in diabetes by targeting Merlin. ExpRev EndoMet Feb16 (2017).
Dharmadhikari G, Stolz K, Hauke M, Morgan NG, Varki A, de Koning E, Kelm S, Maedler K. Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes. Sci Rep. 2017 Apr 5;7:45319
Busse N, Paroni F, Richardson SJ, Laiho JE, Oikarinen M, Frisk G, Hyöty H, de Koning E, Morgan NG, Maedler K. Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes. Oncotarget. 2017
Ting Yuan, Sahar Rafizadeh, Kanaka Durga Devi Gorrepati, Blaz Lupse, Jose Oberholzer, Kathrin Maedler & Amin Ardestani (shared last authors): Reciprocal regulation of mTOR complexes in human type 2 diabetic pancreatic islets, Diabetologia. 2017 Apr;60(4):668-678.
Ardestani, A. & Maedler, K. MST1: a promising therapeutic target to restore functional beta cell mass in diabetes. Diabetologia59, 1843-9 (2016).
Ting Yuan, Sahar Rafizadeh, Zahra Azizi, Blaz Lupse, Kanaka Durga Devi Gorrepati, Sushil Awal, Jose Oberholzer, Kathrin Maedler & Amin Ardestani: Pro-proliferative and anti-apoptotic action of exogenously introduced YAP in pancreatic β-cells. JCI Insight. 2016 Nov3;1(18):e86326.
Azizi Z, Lange C, Paroni F, Ardestani A, Meyer A, Wu Y, Zander AR, Westenfelder C, Maedler K. β-MSCs: successful fusion of MSCs with β-cells results in a β-cell like phenotype. Oncotarget. 2016 Jun 21. doi: 10.18632/oncotarget.10214.
Meyer A, Paroni F, Günther K, Dharmadhikari G, Ahrens W, Kelm S, Maedler K. Evaluation of Existing Methods for Human Blood mRNA Isolation and Analysis for Large Studies. PLoS One. 2016 Aug 30;11(8):e0161778. doi: 10.1371/journal.pone.0161778. eCollection 2016.
Aminian A, Shirzadi B, Azizi Z, Maedler K, Volkmann E, Hildebrand N, Maas M, Treccani L, Rezwan K. Enhanced cell adhesion on bioinert ceramics mediated by the osteogenic cell membrane enzyme alkaline phosphatase. Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:184-94. doi: 10.1016/j.msec.2016.06.056. Epub 2016 Jun 17.
Shah P, Lueschen N, Ardestani A, Oberholzer J, Olerud J, Carlsson PO, Maedler K: Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes. PLoS One. 2016 Sep 12;11(9):e0161834. doi: 10.1371/journal.pone.0161834. eCollection 2016.
Ting Yuan, Kanaka Durga Devi Gorrepati, Kathrin Maedler& Amin Ardestani: Loss of Merlin/NF2 protects pancreatic β-cells from apoptosis by inhibiting LATS2, Cell Death Dis. 2016 Feb 18;7:e2107. doi: 10.1038/cddis.2016.21
Wallbach M, Duque Escobar J, Babaeikelishomi R, Stahnke MJ, Blume R, Schröder S, Kruegel J, Maedler K, Kluth O, Kehlenbach RH, Miosge N, Oetjen E: Distinct functions of the dual leucine zipper kinase depending on its subcellular localization. Cellular Signalling 28 (2016) 272–283

 

Meyer A, Stolz K, Dreher W, Bergemann J, Holebasavanahalli V, Lueschen N, Azizi Z, Khobragade V, Maedler K, Kuestermann E: Manganese mediated magnetic resonance imaging signals correlate with functional b-cell mass during diabetes progression. Diabetes, 2015
Janina Oetjen, Kirill Veselkov, Jeramie Watrous, James S McKenzie, Michael Becker, Lena Hauberg-Lotte, Jan Hendrik Kobarg, Nicole Strittmatter, Anna K Mróz, Franziska Hoffmann6, Dennis Trede, Andrew Palmer, Stefan Schiffler, Klaus Steinhorst, Michaela Aichler, Robert Goldin, Orlando Guntinas-Lichius, Ferdinand von Eggeling, Herbert Thiele, Kathrin Maedler, Axel Walch, Peter Maass, Pieter C Dorrestein, Zoltan Takats and Theodore Alexandrov: Benchmark datasets for 3D MALDI- and DESI-imaging mass spectrometry, GigaScience (2015) 4:20
Dominika Nackiewicz & Meixia Dan & Wei He & Rosa Kim & Anisa Salmi, Sabine Rütti & Clara Westwell-Roper & Amanda Cunningham & Madeleine Speck, Carole Schuster-Klein & Beatrice Guardiola & Kathrin Maedler & Jan A. Ehses. TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6. Diabetologia (2014) 57:1645–165
Zhao G, Dharmadhikari G, Maedler K, Meyer-Hermann M: Possible role of interleukin-1β in type 2 diabetes onset and implications for anti-inflammatory therapy strategies. PLoS Comput Biol. 2014
Ardestani,A, Paroni,F, Azizi,Z, Kaur,S, Khobragade,V, Yuan,T, Frogne,T, Tao,W, Oberholzer,J, Pattou,F, Kerr-Conte,J, Maedler,K: MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes. Nature Medicine, 2014 VOLUME 20 , NUMBER 4 , APRIL 2014
Hoffmeister A, Tuennemann J, Sommerer I, Mössner J, Rittger A, Schleinitz D, Kratzsch J, Rosendahl J, Klöting N, Stahl T, Rossner S, Paroni F, Maedler K, Kovacs P, Blüher M. Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression. Obesity (Silver Spring). 2013 Dec;21(12):E626-33.
Shah,P, Ardestani,A, Dharmadhikari,G, Laue,S, Schumann,DM, Kerr-Conte,J, Pattout,F, Klein,T, Maedler,K: The DPP-4 inhibitor linagliptin restores b-cell function & survival in human isolated islets through GLP-1 stabilization, J Clin Endocrinol Metab 98, E1163-1172, 2013
Robert Spinnler, Theresa Gorski, Katharina Stolz, Susanne Schuster, Antje Garten, Annette G. Beck-Sickinger, Marten A. Engelse, Eelco J. P. de Koning, Antje Korner, Wieland Kiess, Kathrin Maedler: The Adipocytokine Nampt and Its Product NMN Have No Effect on Beta-Cell Survival but Potentiate Glucose Stimulated Insulin Secretion: PLoS ONE 8(1): e54106. doi:10.1371/journal.pone.0054106

 

Malaisse WJ, Maedler K (2012) Imaging of the beta-cells of the islets of Langerhans. Diabetes Res Clin Pract.
H. Sahin, E. Borkham-Kamphorst, N.T. do O, M.-L. Berres, M. Kaldenbach, P. Schmitz, R. Weiskirchen, C. Liedtke, K.L. Streetz, K. Maedler, C. Trautwein and H.E. Wasmuth: Pro-apoptotic effects of the chemokine CXCL10 are mediated by the non-cognate receptor TLR4 in hepatocytes. Hepatology. 2012
Dharmadhikari, G, Mühle, M, Schulthess, FT, Laue, S, Oberholzer, J, Pattou, F, Kerr-Conte, J and Maedler K, TOSO promotes b-cell proliferation and protects from apoptosis, MOLECULAR METABOLISM 1 (2012) 70–78
Shu L, Zien K, Gutjahr G, Oberholzer J, Pattou F, Kerr Conte J, Maedler K, TCF7L2 promotes beta-cell regeneration in the human and mouse pancreas. Diabetologia 2012
Boutant M, Pereira Ramos OH, Tourrel-Cuzin C, Movassat J, Ilias A, Vallois D, Planchais J, Pegorier JP, Schuit F, Patric,  Petit PX, Bossard P, Maedler K, Grapin-Botton A, Vasseur-Cognet M: COUP-TFII Controls Mouse Pancreatic b-Cell Mass through GLP-1-b-Catenin Signaling Pathways. PLOS ONE, January 24, 2012
Kathrin Maedler. Rettet die Beta-Zelle: Save the β-Cell New Concepts for Diabetes. Editorial. Diabetologie und Stoffwechsel 2011; 6(5): 283-286.

Goehring I, Sauter NS, Catchpole G, Assmann A, Shu L, Zien KS, Moehlig M, Pfeiffer AF, Oberholzer J, Willmitzer L, Spranger J, Maedler K. Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets. Diabetologia. 2011 Oct;54(10):2584-94. Epub 2011 Jul 28.

Hansen AM, Bödvarsdottir TB, Nordestgaard DN, Heller RS, Gotfredsen CF, Maedler K, Fels JJ, Holst JJ, Karlsen AE. Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus-an adaptive response to hyperglycaemia? Diabetologia. 2011 Feb 25. [Epub ahead of print]
Le Bacquer O, Shu L, Marchand M, Neve B, Paroni F, Conte JK, Pattou F, Froguel P, Maedler K.: TCF7L2 splice variants have distinct effects on beta-cell turnover and function. Hum Mol Genet. 2011.
Efficient gene delivery and silencing of mouse and human pancreatic islets. Bruno Lefebvre, Brigitte Vandewalle, Justine Longue, Ericka Moerman, Bruno Lukowiack, Valery Gmyr, Julie Kerr-conte, Kathrin Maedler, François Pattou, BMC Biotechnol. 2010 Mar 30;10(1):28.
Owyang A*,, Maedler K*  et al.: XOMA 052, an Anti-IL-1 beta Monoclonal Antibody, Improves Glucose Control and Beta Cell Function in the Diet-Induced Obesity Mouse Model, Endocrinology. 2010;151(6):2515-27 (*shared 1st authors)

 

 

Paroni, F, Domsgen E, Maedler K: CXCL10- a path to β-cell death, Islets. 2009;1(3):256-9.
Maedler K, Dharmadhikari G, Schumann DM & Størling J, Interleukin-1 beta targeted therapy for type 2 diabetes, Expert Opin. Biol. Ther. (2009) 9 (9):1177-1188
Mee L, Nabokina SM, Sekar VT, Subramanian VS, Maedler K, Said HM: Pancreatic beta cells/islets take up thiamin by a regulated carrier-mediated process: Studies using mice and human pancreatic preparations, Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G197-206.
Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CHS, Maedler K: Decreased TCF7L2 protein levels in T2DM correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function, Hum Mol Gen 2009, 18(13):p.2388-99
Glas R, Sauter NS, Schulthess FT, Shu L, Oberholzer J and Maedler K: Purinergic P2X7 receptors regulate secretion of Interleukin-1 Receptor antagonist and beta cell function and survival, Diabetologia, 2009. 52(8): p.1579-88
Schulthess FT, Paroni F, Sauter NS, Shu L, Ribaux P, Haataja L, Strieter RM, Oberholzer J, King CC, Maedler K. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab. 2009 Feb;9(2):125-39.
Schulthess, FT., Katz, S., Ardestani,A., KawahiraH., GeorgiaS, BoscoD., BhushanA and Maedler  K, Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces β-cell apoptosis and impairs β-cell mass.  PLoSONE.2009

Sauter NS, Schulthess FT, Galasso R, Castellani LW, Maedler K. The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia. Endocrinology. 2008 May;149(5):2208-18. Epub 2008 Jan 31.

Li Y, Maedler K, Shu L, Haataja L. UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells. PLoS ONE. 2008 Jan 2;3(1):e1397.
Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Allayee H, Maedler K: Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia. 2008 Jun;51(6):978-88. Epub 2008 Apr 18. shared last authorship
Maedler K, Schulthess FT, Bielman C, Berney T, Bonny C, Prentki M, Donath MY, Roduit R. Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases. FASEB J. 2008 Jun;22(6):1905-13.
Brun T, He KHH, Lupi R, Boehm B, Wojtusciszyn A, Sauter N, Donath M, Marchetti P, Maedler K, Gauthier BR: The Diabetes-Linked Transcription Factor Pax4 is Expressed in Human Pancreatic Islets and is Activated by Mitogens and GLP-1, Hum Mol Genet. 2008 Feb 15;17(4):478-89
Maedler K: Beta cells in type 2 diabetes-a crucial contribution to pathogenesis. Diabetes Obes Metab. 2008 May;10(5):408-20
Schumann DM Maedler K, Franklin I, Ehses JA, Ellingsgaard H, Gjinovci A, Kurrer MO, Gauthier BR, Iwakura Y, Chervonsky AV, Wollheim CB, Donath MY: The Fas pathway is involved in beta-cell secretory function. PNAS Feb 20;104(8):2861-6, 2007
Maedler,K, Schumann,DM, Sauter,N, Ellingsgaard,H, Bosco,D, Baertschiger,R, Iwakura,Y, Oberholzer,J, Wollheim,CB, Gauthier,BR, Donath,MY Low concentration of IL-1b induces FLIP-mediated b cell proliferation in human pancreatic islets, Diabetes 55:2713-22, 2006
Maedler,K, Schumann,DM, Schulthess,FT, Oberholzer,J, Bosco,D, Berney,T, Donath,MY Aging correlates with decreased b-cell proliferative capacity and enhanced sensitivity to apoptosis: A potential role for Fas and PDX-1, Diabetes 55:2455-62, 2006
Meier,JJ, Ritzel,RA, Maedler,K, Gurlo,T, Butler,PC: Increased vulnerability of newly forming beta-cells to cytokine-induced cell death. Diabetologia 49(1):83-9, 2006
Donath,MY, Ehses,JA, Maedler,K, Schumann,DM, Ellingsgaard,H, Eppler,E, Reinecke,M: Mechanisms of beta-cell death in type 2 diabetes. Diabetes 54 Suppl 2:S108-13, 2005
Mohanty,S, Spinas,GA, Maedler,K, Zuellig,R, Lehmann,R, Donath,MY, Trüb,T, Niessen,M: Overexpression of IRS-2 in isolated pancreatic islets causes proliferation and protects human b-cells from hyperglycemia- induced apoptosis. Exp Cell Res 303: 68-78 (2005)
Maedler,K, Bucher,P, Berney,T, Spinas,GA, Carr,RD, Donath,MY: Sulphonylurea induced β-cell apoptosis in cultured human islets. J Clin Endocrinol Metab. 90(1): 501-6 (2005)
Zeender,E, Maedler,K, Bosco,D, Berney,T, Donath,MY, Halban,PA: Pioglitazone and Sodium Salicylate Protect Human β-Cells against Apoptosis and Impaired Function Induced by Glucose and Interleukin-1β. J Clin Endocrinol Metab 89:5059-5066, 2004, shared first authorship
Maedler,K, Donath,MY: Beta cells in type 2 diabetes-a loss of funtion and mass Horm.Res.62 Suppl 3: 67-73, 2004.
Hammar,E, Parnaud,G, Bosco,D, Maedler,K, Donath,MY, Halban,PA, Rouiller,DG: 804G matrix protects primary pancreatic b-cells against apoptosis by increased expression of IB and/or via activation of AKT. Diabetes 53: 2034-41, 2004
Bai,L, Maedler,K, Donath,MY, Tuch,BE: Expression of Fas but not FasL on Fetal Pig b-cells. Xenotransplantation 11: 426-73, 2004
Maedler,K, Størling,J, Sturis,J, Zuellig,R, Spinas,GA, Arkhammar,POG, Mandrup-Poulsen,T, Donath,MY: Glucose- and IL-1b-induced b cell Apoptosis Require Ca2+ influx, ERK1/2 activation and are Prevented by a b cell Selective Potassium Channel Opener in Human Islets. Diabetes 53: 1706-13, 2004
Lehmann,R, Weber,M, Berthold,P, Züllig,R, Pfammater,T, Moritz,W, Maedler,K, Donath,MY, Ambühl,P, Demartiness,N, Clavien,PA, Spinas,GA. Successful Simultaneous Islet-Kidney Transplantation using a Steroid-free Immunosuppression: Two Year Follow-up. Am.J.Trans  Jul;4(7):1117-23, 2004
Maedler,K, Sergeev,P, Ehses,JA, Mathe,Z, Bosco,D, Berney,T, Dayer,JM, Reinecke,M, Halban,PA, Donath,MY: Leptin modulates b cell expression of IL-1 receptor antagonist and release of IL-1b and in human islets. Proc.Natl.Acad.Sci.U.S.A 101: 8138-43, 2004

 

Donath,MY, Størling,J, Maedler,K, Mandrup-Poulsen,T: Inflammatory mediators and islet beta-cell failure: a link between Type 1 and Type 2 diabetes. J Mol Med 81:455-470, 2003
Maedler,K, Oberholzer,J, Bucher,P, Spinas,GA, Donath,MY: Monounsaturated Fatty  Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic b-Cell Turnover and Function. Diabetes 52:726-733, 2003
Donath,MY, Maedler,K, Sergeev,P, Dyntar,D, Thomas,D, Spinas,GA: The pathogenesis of type 2 diabetes--new aspects and clinical consequences. Ther.Umsch. 59:381-385, 2002
Ris,F, Hammar,E, Bosco,D, Pilloud,C, Maedler,K, Donath,MY, Oberholzer,J, Zeender,E, Morel,P, Rouiller,D, Halban,PA: Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro. Diabetologia 45:841-850, 2002
Maedler,K, Sergeev,P, Ris,F, Oberholzer,J, Joller-Jemelka,HI, Spinas,GA, Kaiser,N, Halban,PA, Donath,MY: Glucose-induced beta-cell production of interleukin-1beta contributes to glucotoxicity in human pancreatic islets. J.Clin.Invest 110:851-860, 2002
Maedler,K, Fontana,A, Ris,F, Sergeev,P, Toso,C, Oberholzer,J, Lehmann,R, Bachmann,F, Tasinato,A, Spinas,GA, Halban,PA, and Donath,MY: FLIP switches Fas-mediated glucose signaling in human pancreatic b-cells from apoptosis to cell replication. Proc.Natl.Acad.Sci.U.S.A 99:8236-8241, 2002
Dyntar,D, Eppenberger-Eberhardt,M, Maedler,K, Pruschy,M, Eppenberger,HM, Spinas,GA, Donath,MY: Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes. Diabetes 50:2105-2113, 2001
Maedler,K, Spinas,GA, Lehmann,R, Sergeev,P, Weber,M, Fontana,A, Kaiser,N, Donath,MY: Glucose induces b-cell apoptosis via upregulation of the Fas-receptor in human islets. Diabetes 50:1683-1690, 2001
Maedler,K, Spinas,GA, Dyntar,D, Moritz,W, Kaiser,N, Donath,MY: Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. Diabetes 50:69-76, 2001

Books

Federico Paroni & Kathrin Maedler: CXCL10 Chemokine (C-X-C motif) ligand 10, Springer Book Encyclopedia of Signaling Molecules, 201
Amin Ardestani, Luan Shu and Kathrin Maedler: Targeting the metabolic syndrome and type 2 diabetes by preventing inflammation, Elsevier Book: NUTRITIONAL AND THERAPEUTIC INTERVENTIONS OF DIABETES AND METABOLIC SYNDROME 2011
Maedler K, Dharmadhikari G, Schumann DM, Størling J.: Interleukin-targeted therapy for metabolic syndrome and type 2 diabetes. In Handb Exp Pharmacol. 2011;(203):257-78