Zum Inhalt springen

Proteostasis

  • Confocal microscopy of neurons of the nematode C.elegans

    Analysis of neuronal proteins by fluorescent fusion proteins. Depicted in green is the actin-binding protein Drebrin and in red Abeta1-42 that is associated with Alzheimer disease.

Welcome to the Janine Kirstein Group!

The long-term health of all metazoan cells is inextricably linked to protein quality control. An imbalance in protein homeostasis (proteostasis) can result in severe molecular damage to the cell, directly leading to tissue pathology and to enhanced susceptibility to diseases not only including metabolic disease and neurodegeneration, but also cancer and immunodeficiency. Our group aims to uncover the complex mechanisms of the proteostasis network, strategies to cope with protein aggregates and its changes during development and with the progression of aging. 

Figure showing a functional proteome in the proteostasis network.
A functional proteome in the proteostasis network.

Contact

Molecular Physiology and Cell Biology

Prof. Dr. Janine Kirstein

Universität Bremen
Fachbereich 2, NW2 Block A
Leobener Straße 5
D-28359 Bremen