Glucose and monocarboxylate metabolism
Glucose is the main peripheral substrate for ATP production in brain and is continuously delivered via the blood stream to the brain. Brain cells efficiently metabolise glucose via glycolysis to pyruvate that is either reduced to lactate or transported into mitochondria for further oxidation. We are investigating the modulation of glycolytic lactate production by drugs and toxins that affect glycolysis and/or mitochondrial functions. In addition, we study the mitochondrial metabolism of monocarboxylates such as pyruvate and ketone bodies.
Recent publications
N. Denker, R. Dringen (2024)
Modulation of pyruvate export and extracellular pyruvate concentration in primary astrocyte cultures.
Neurochem. Res. 49, 1331-1346.
doi: 10.1007/s11064-024-04120-0
N. Denker, A. R. Harders, C. Arend, R. Dringen (2023)
Consumption and metabolism of extracellular pyruvate by cultured rat brain astrocytes.
Neurochem. Res. 48, 1438-1454.
doi: 10.1007/s11064-022-03831-6
E.-M. Blumrich, R. Dringen (2019)
Metformin accelerates glycolytic lactate production in cultured primary cerebellar granule neurons.
Neurochem. Res. 44, 188-199.
doi: 10.1007/s11064-017-2346-1
C. Arend, E. Ehrke, R. Dringen (2019)
Consequences of a metabolic glucose-depletion on the survival and the metabolism of cultured rat astrocytes.
Neurochem. Res. 44, 2288-2300.
doi: 10.1007/s11064-019-02752-1