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Cell Biology

  • C.elegans

    Our lab studies Huntington's and Alzheimer's disease using the nematode as well as cell culture and in vitro techniques

  • Using redox-GFP to access the redox state of the ER with aging. Blue fluorescence indicates a more oxidative environment that is required for correct protein folding in the ER whereas green indicates a shift towards more reducing conditions that will harm the fold and fucntion of proteins in the ER.

Welcome to the lab website of Janine Kirstein

The long-term health of all metazoan cells is inextricably linked to protein quality control. An imbalance in protein homeostasis (proteostasis) can result in severe molecular damage to the cell, directly leading to tissue pathology and to enhanced susceptibility to diseases not only including metabolic disease and neurodegeneration, but also cancer and immunodeficiency. Our group aims to uncover the complex mechanisms of the proteostasis network, strategies to cope with protein aggregates and its changes with aging. 

Figure showing a functional proteome in the proteostasis network.
The proteostasis network ensures the fold and function of the proteome.

Contact

Prof. Dr. Janine Kirstein

Universität Bremen
Fachbereich 2, NW2 Block A
Leobener Straße 5
D-28359 Bremen

phone: +49-(0)421-21862880

email: kirstein@uni-bremen.de