Janine will present and showcase to visitors of the MindDay how we use the nematode to study neurodegenerative diseases.
The program can be found here.
Our lab contributed with FLIM analyses in our Abeta nematodes on the analyses how MOAG-4 (SERF2) affect the aggregation of amyloid proteins. MOAG-4 interacts with negatively charged regions of aggregation-prone proteins to facilitate their aggregation. Neutralization of the positive charge of moag-4 in C. elegans abrogates this effect. Congratulations to all authors. The new publication can be found here.
July 12th 2021
The Kirstein lab will cooperate with the Eickholt lab (Charite Universitätsmedizin Berlin) to study presynaptic proteostasis as part of the newly established research unit (FOR 5228): Syntophagy
We'll study the crosstalk of autophagy and the UPS to maintain neuronal function.
The research unit is composed of labs of Berlin (FU Berlin, HU Berlin, Charite Universitätsmedizin Berlin and the FMP), Magdeburg (Universität Magdeburg + LIN) and Haifa, IL (Technion) as well as Universität Bremen.
New collaborative study with the lab of Klaudia Brix at Jacobs University and many more labs published in IJMS. I happily contributed and say congrats to first author Vaishnavi Venugopalan!
Venugopalan V, Al-Hashimi A, Rehders M, Golchert J, Reinecke V, Homuth G, Völker U, Manirajah M, Touzani A, Weber J, Bogyo MS, Verrey F, Wirth EK, Schweizer U, Heuer H, Kirstein J, Brix K
The thyroid hormone transporter Mct8 restricts cathepsin-mediated thyroglobulin processing in male mice through thyroid auto-regulatory mechanisms that encompass thyrotoxicity-induced autophagy
International Journal of Molecular Sciences, in press
Off to a good start in 2021!
We are excited and grateful to receive funding to study the role of molecular chaperones in neurodegenerative diseases.
Johann will study what renders the IL2 neurons so vulnerable for Abeta aggregation and he will also study the contribution of specific molecular chaperones on Abeta aggregation and propagation. Welcome Johann!