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Organische Chemie

Welcome to Nachtsheims Group


ACS Catalysis

Ayham’s article “An Enantioconvergent Benzylic Hydroxylation Using a Chiral Aryl Iodide in a Dual Activation Mode” just appeared on ACS Catalysis. It is the first enantioconvergent hydroxylation ever described. This synthetic catalyst outperforms even enzymes in direct benzylic hydroxylations regarding reactivity and enantioselectivity. Great Job!”

AK Nachtsheim

AK Nachtsheim

„We’re in Corona-Mode!“

J. Mater. Chem. C

Dominik´s article "Nitrile-Substituted 2-(Oxazolinyl)-Phenols: Minimalistic Excited-State Intramolecular Proton Transfer (ESIPT)-Based Fluorophores" is accepted.

J. Mater. Chem. C, 2020, 8, 9213 - 9225


Ayham´s articel  "A Triazole‐Substituted Aryl Iodide with Omnipotent Reactivity in Enantioselective Oxidations" is accepted. 

Angew. Chem. Int. Ed., 2019  DOI: 10.1002/anie.201912023 . Congratulations!!

Organic Letters Cover!

Dominik and Nils recent results are published in Organic Letters. Congratulations for the great coverpicture.


Chemistry - A European Journal

Abstract Andreas




Andreas recent findings about pseudocyclic N-heterocycle stabilized iodanes has just been accepted in Chemistry – A European Journal


Organic & Biomolecular Chemistry




Dominik Göbel M. Sc. received the Thieme Chemistry Poster Prize at the ORCHEM in Berlin  (September 2018). Congratulation!

Some of the results are puplished in:




The inside cover picture, provided by Pericàs and Nachtsheim, illustrates the development of novel C1-symmetric iodoarenes as precursors for chiral aryl-λ3-iodanes. The synthesis of these structures is highly modular and allows easy modification on all major substituents, namely the arene, the alkyl ether and the terminal triazole. This is not only the first example for a triazole-based chiral iodoarene but also the so far most efficient C1-symmetric catalyst for the oxidative enantioselective spirocyclization of 1-naphtholcarboxylic acids to spirolactones. C. Hempel, C. Maichle-Moessmer, M. A. Pericàs, B. J. Nachtsheim, Adv. Synth. Catal2017359, 2931-2941; DOI: 10.1002/adsc.201700246.



C−H Activation Directing groups are crucial in transition metal-catalyzed C−H activations to control regio-and stereoselectivity. So far, free amines have rarely been used as directing groups since they tend to deactivate the transition metal or undergo undesired side reactions. We demonstrate that free amines in anilines can be used as directing groups in delicate C−H activating alkynylations to give versatile 1,3-enynes in excellent yields and stereoselectivities using highly reactive hypervalent iodine-based alkynylation reagents . L. D. Caspers, P. Finkbeiner, B. J. Nachtsheim, Chem. Eur.J.2017, 23, 2748 –2752; DOI:  10.1002/chem.201781262