Publications

Selected Publications (since 2001)

1. Maedler,K, Spinas,GA, Dyntar,D, Moritz,W, Kaiser,N, Donath,MY: Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. Diabetes 50:69-76, 2001 http://diabetes.diabetesjournals.org/cgi/content/full/50/1/69

2. Maedler,K, Spinas,GA, Lehmann,R, Sergeev,P, Weber,M, Fontana,A, Kaiser,N, Donath,MY: Glucose induces ß-cell apoptosis via upregulation of the Fas-receptor in human islets. Diabetes 50:1683-1690, 2001. http://diabetes.diabetesjournals.org/cgi/content/full/50/8/1683

3. Dyntar,D, Eppenberger-Eberhardt,M, Maedler,K, Pruschy,M, Eppenberger,HM, Spinas,GA, Donath,MY: Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes. Diabetes 50:2105-2113, 2001. http://diabetes.diabetesjournals.org/cgi/content/full/50/9/2105

4. Maedler,K, Fontana,A, Ris,F, Sergeev,P, Toso,C, Oberholzer,J, Lehmann,R, Bachmann,F, Tasinato,A, Spinas,GA, Halban,PA, and Donath,MY: FLIP switches Fas-mediated glucose signaling in human pancreatic ß-cells from apoptosis to cell replication. Proc.Natl.Acad.Sci.U.S.A 99:8236-8241, 2002. http://www.pnas.org/content/99/12/8236

5. Maedler,K, Sergeev,P, Ris,F, Oberholzer,J, Joller-Jemelka,HI, Spinas,GA, Kaiser,N, Halban,PA, Donath,MY: Glucose-induced beta-cell production of interleukin-1beta contributes to glucotoxicity in human pancreatic islets. J.Clin.Invest 110:851-860, 2002. http://dx.doi.org/10.1172/JCI15318

6. Ris,F, Hammar,E, Bosco,D, Pilloud,C, Maedler,K, Donath,MY, Oberholzer,J, Zeender,E, Morel,P, Rouiller,D, Halban,PA: Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro. Diabetologia 45:841-850, 2002. http://dx.doi.org/10.1007/s00125-002-0840-7

7. Donath,MY, Maedler,K, Sergeev,P, Dyntar,D, Thomas,D, Spinas,GA: The pathogenesis of type 2 diabetes--new aspects and clinical consequences. Ther.Umsch. 59:381-385, 2002.

8. Maedler,K, Oberholzer,J, Bucher,P, Spinas,GA, Donath,MY: Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic ß-Cell Turnover and Function. Diabetes 52:726-733, 2003. http://diabetes.diabetesjournals.org/cgi/content/full/52/3/726

9. Donath,MY, Størling,J, Maedler,K, Mandrup-Poulsen,T: Inflammatory mediators and islet beta-cell failure: a link between Type 1 and Type 2 diabetes. J Mol Med 81:455-470, 2003. http://dx.doi.org/10.1007/s00109-003-0450-y

10. Maedler,K, Sergeev,P, Ehses,JA, Mathe,Z, Bosco,D, Berney,T, Dayer,JM, Reinecke,M, Halban,PA, Donath,MY: Leptin modulates ß cell expression of IL-1 receptor antagonist and release of IL-1ß and in human islets. Proc.Natl.Acad.Sci.U.S.A 101: 8138-43, 2004. http://dx.doi.org/10.1073/pnas.0305683101

11. Lehmann,R, Weber,M, Berthold,P, Züllig,R, Pfammater,T, Moritz,W, Maedler,K, Donath,MY, Ambühl,P, Demartiness,N, Clavien,PA, Spinas,GA. Successful Simultaneous Islet-Kidney Transplantation using a Steroid-free Immunosuppression: Two Year Follow-up. Am.J.Trans Jul;4(7):1117-23, 2004.

12. Maedler,K, Størling,J, Sturis,J, Zuellig,R, Spinas,GA, Arkhammar,POG, Mandrup-Poulsen,T, Donath,MY: Glucose- and IL-1ß-induced ß cell Apoptosis Require Ca2+ influx, ERK1/2 activation and are Prevented by a ß cell Selective Potassium Channel Opener in Human Islets. Diabetes 53: 1706-13, 2004. http://diabetes.diabetesjournals.org/cgi/content/full/53/7/1706

13. Bai,L, Maedler,K, Donath,MY, Tuch,BE: Expression of Fas but not FasL on Fetal Pig ß-cells. Xenotransplantation 11: 426-73, 2004. http://dx.doi.org/10.1111/j.1399-3089.2004.00158.x

14. Hammar,E, Parnaud,G, Bosco,D, Maedler,K, Donath,MY, Halban,PA, Rouiller,DG: 804G matrix protects primary pancreatic ß-cells against apoptosis by increased expression of I-B and/or via activation of AKT. Diabetes 53: 2034-41, 2004. http://diabetes.diabetesjournals.org/cgi/content/full/53/8/2034

15. Maedler,K, Donath,MY: Beta cells in type 2 diabetes-a loss of funtion and mass Horm.Res. 62 Suppl 3: 67-73, 2004. http://dx.doi.org/10.1159/000080503

16. Zeender,E, Maedler,K, Bosco,D, Berney,T, Donath,MY, Halban,PA: Pioglitazone and Sodium Salicylate Protect Human ß-Cells against Apoptosis and Impaired Function Induced by Glucose and Interleukin-1ß. J Clin Endocrinol Metab 89:5059-5066, 2004, shared first authorship. http://dx.doi.org/10.1210/jc.2004-0446

17. Maedler,K, Bucher,P, Berney,T, Spinas,GA, Carr,RD, Donath,MY: Sulphonylurea induced ß-cell apoptosis in cultured human islets. J Clin Endocrinol Metab. 90(1): 501-6 (2005) http://dx.doi.org/10.1210/jc.2004-0699

18. Mohanty,S, Spinas,GA, Maedler,K, Zuellig,R, Lehmann,R, Donath,MY, Trüb,T, Niessen,M: Overexpression of IRS-2 in isolated pancreatic islets causes proliferation and protects human ß-cells from hyperglycemia- induced apoptosis. Exp Cell Res 303: 68-78 (2005) http://dx.doi.org/10.1016/j.yexcr.2004.09.011

19. Donath,MY, Ehses,JA, Maedler,K, Schumann,DM, Ellingsgaard,H, Eppler,E, Reinecke,M: Mechanisms of beta-cell death in type 2 diabetes. Diabetes 54 Suppl 2:S108-13, 2005. http://diabetes.diabetesjournals.org/cgi/content/full/54/suppl_2/S108

20. Meier,JJ, Ritzel,RA, Maedler,K, Gurlo,T, Butler,PC: Increased vulnerability of newly forming beta-cells to cytokine-induced cell death. Diabetologia 49(1):83-9, 2006. http://dx.doi.org/10.1007/s00125-005-0069-3

21. Maedler,K, Schumann,DM, Schulthess,FT, Oberholzer,J, Bosco,D, Berney,T, Donath,MY Aging correlates with decreased ß-cell proliferative capacity and enhanced sensitivity to apoptosis: A potential role for Fas and PDX-1, Diabetes 55:2455-62, 2006. http://dx.doi.org/10.2337/db05-1586

22. Maedler,K, Schumann,DM, Sauter,N, Ellingsgaard,H, Bosco,D, Baertschiger,R, Iwakura,Y, Oberholzer,J, Wollheim,CB, Gauthier,BR, Donath,MY Low concentration of IL-1ß induces FLIP-mediated v cell proliferation in human pancreatic islets, Diabetes 55:2713-22, 2006. http://dx.doi.org/10.2337/db05-1430

23. Schumann DM Maedler K, Franklin I, Ehses JA, Ellingsgaard H, Gjinovci A, Kurrer MO, Gauthier BR, Iwakura Y, Chervonsky AV, Wollheim CB, Donath MY: The Fas pathway is involved in beta-cell secretory function. PNAS Feb 20;104(8):2861-6, 2007.http://dx.doi.org/10.1073/pnas.0611487104

24. Maedler K: Beta cells in type 2 diabetes-a crucial contribution to pathogenesis. Diabetes Obes Metab. 2008 May;10(5):408-20. http://dx.doi.org/10.1111/j.1463-1326.2007.00718.x

25. Brun T, He KHH, Lupi R, Boehm B, Wojtusciszyn A, Sauter N, Donath M, Marchetti P, Maedler K, Gauthier BR: The Diabetes-Linked Transcription Factor Pax4 is Expressed in Human Pancreatic Islets and is Activated by Mitogens and GLP-1, Hum Mol Genet. 2008 Feb 15;17(4):478-89. http://dx.doi.org/10.1093/hmg/ddm325

26. Maedler K, Schulthess FT, Bielman C, Berney T, Bonny C, Prentki M, Donath MY, Roduit R. Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases. FASEB J. 2008 Jun;22(6):1905-13. http://dx.doi.org/10.1096/fj.07-101824

27. Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Maedler K, Allayee H. Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Diabetologia. 2008 Jun;51(6):978-88. Epub 2008 Apr 18. shared last authorship. http://dx.doi.org/10.1007/s00125-008-1002-3

28. Li Y, Maedler K, Shu L, Haataja L. UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells. PLoS ONE. 2008 Jan 2;3(1):e1397. http://dx.doi.org/10.1371/journal.pone.0001397

29. Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K. Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets. Diabetes. 2008 Mar;57(3):645-53. Epub 2007 Dec 10. http://dx.doi.org/10.2337/db07-0847

30. Sauter NS, Schulthess FT, Galasso R, Castellani LW, Maedler K. The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia. Endocrinology. 2008 May;149(5):2208-18. Epub 2008 Jan 31. http://dx.doi.org/10.1210/en.2007-1059

31. Schulthess, FT., Katz, S., Ardestani, A., Kawahira H., Georgia S, Bosco D., Bhushan A and Maedler K, Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces ß-cell apoptosis and impairs ß-cell mass. PLoSONE. In Press 2009. http://dx.doi.org/10.1371/journal.pone.0004394

32. Schulthess FT, Paroni F, Sauter NS, Shu L, Ribaux P, Haataja L, Strieter RM, Oberholzer J, King CC, Maedler K. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab. 2009 Feb;9(2):125-39. http://dx.doi.org/10.1016/j.cmet.2009.01.003

33. Glas R, Sauter NS, Schulthess FT, Shu L, Oberholzer J, Maedler K. Schulthess Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival. Diabetologia in Press, 2009. http://dx.doi.org/10.1007/s00125-009-1349-0

34. Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CHS, Maedler K: Decreased TCF7L2 protein levels in T2DM correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function, Hum Mol Gen 2009, 18(13):p.2388-99

35. Mee L, Nabokina SM, Sekar VT, Subramanian VS, Maedler K, Said HM: Pancreatic beta cells/islets take up thiamin by a regulated carrier-mediated process: Studies using mice and human pancreatic preparations, Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G197-206.

36. Maedler K, Dharmadhikari G, Schumann DM & Størling J, Interleukin-1 beta targeted therapy for type 2 diabetes, Expert Opin. Biol. Ther. (2009) 9 (9):1177-1188

37. Paroni, F, Domsgen E, Maedler K: CXCL10- a path to β-cell death, Islets. 2009;1(3):256-9.

38. Maedler K, Owyang A, Gross L, Yin J, Esposito L, Shu L, Jadhav J, Domsgen E, Bergemann J, Lee S, Kantak S: XOMA 052, an Anti-IL-1 beta Monoclonal Antibody, Improves Glucose Control and Beta Cell Function in the Diet-Induced Obesity Mouse Model, Endocrinology. 2010 Jun;151(6):2515-27

39. Efficient gene delivery and silencing of mouse and human pancreatic islets. Bruno Lefebvre, Brigitte Vandewalle, Justine Longue, Ericka Moerman, Bruno Lukowiack, Valery Gmyr, Julie Kerr-conte, Kathrin Maedler, François Pattou, BMC Biotechnol. 2010 Mar 30;10(1):28.

40. Ardestani A, Sauter NS, Paroni F, Dharmadhikari G, Cho JH, Lupi R, Oberholzer J, Kerr Conte J, Maedler K: Neutralizing IL-1{beta} induces {beta}-cell survival by maintaining PDX1 nuclear localization. J Biol Chem. 2011 Mar 10. [Epub ahead of print]

41. Le Bacquer O, Shu L, Marchand M, Neve B, Paroni F, Conte JK, Pattou F, Froguel P, Maedler K.: TCF7L2 splice variants have distinct effects on {beta}-cell turnover and function. Hum Mol Genet. 2011 Feb 28. 42.

42. Hansen AM, Bödvarsdottir TB, Nordestgaard DN, Heller RS, Gotfredsen CF, Maedler K, Fels JJ, Holst JJ, Karlsen AE. Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus-an adaptive response to hyperglycaemia? Diabetologia. 2011 Feb 25. [Epub ahead of print]

43. Goehring I, Sauter NS, Catchpole G, Assmann A, Shu L, Zien KS, Moehlig M, Pfeiffer AF, Oberholzer J, Willmitzer L, Spranger J, Maedler K. Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets. Diabetologia. 2011 Oct;54(10):2584-94. Epub 2011 Jul 2

44. Boutant M, Pereira Ramos OH, Tourrel-Cuzin C, Movassat J, Ilias A, Vallois D, Planchais J, Pegorier JP, Schuit F, Patric, Petit PX, Bossard P, Maedler K, Grapin-Botton A, Vasseur-Cognet M: COUP-TFII Controls Mouse Pancreatic b-Cell Mass through GLP-1-b-Catenin Signaling Pathways. PLOS ONE, January 24, 2012

45. Shu L, Zien K, Gutjahr G, Oberholzer J, Pattou F, Kerr Conte J, Maedler K, TCF7L2 promotes beta-cell regeneration in the human and mouse pancreas. Diabetologia 2012

46. Dharmadhikari, G, Mühle, M, Schulthess, FT, Laue, S, Oberholzer, J, Pattou, F, Kerr-Conte, J and Maedler K, TOSO promotes b-cell proliferation and protects from apoptosis, Accepted. Molecular Metabolism 2012

47. H. Sahin, E. Borkham-Kamphorst, N.T. do O, M.-L. Berres, M. Kaldenbach, P. Schmitz, R. Weiskirchen, C. Liedtke, K.L. Streetz, K. Maedler, C. Trautwein and H.E. Wasmuth: Pro-apoptotic effects of the chemokine CXCL10 are mediated by the non-cognate receptor TLR4 in hepatocytes. Hepatology

48. Malaisse WJ, Maedler K (2012) Imaging of the beta-cells of the islets of Langerhans. Diabetes Res Clin Pract.

49. Kathrin Maedler. Rettet die Beta-Zelle: Save the β-Cell New Concepts for Diabetes. Editorial. Diabetologie und Stoffwechsel 2011; 6(5): 283-286.

50. Robert Spinnler, Theresa Gorski, Katharina Stolz, Susanne Schuster, Antje Garten, Annette G. Beck-Sickinger, Marten A. Engelse, Eelco J. P. de Koning, Antje Korner, Wieland Kiess, Kathrin Maedler: The Adipocytokine Nampt and Its Product NMN Have No Effect on Beta-Cell Survival but Potentiate Glucose Stimulated Insulin Secretion: PLoS ONE 8(1): e54106. doi:10.1371/journal.pone.0054106

51. Shah,P, Ardestani,A, Dharmadhikari,G, Laue,S, Schumann,DM, Kerr-Conte,J, Pattout,F, Klein,T, Maedler,K: The DPP-4 inhibitor linagliptin restores b-cell function & survival in human isolated islets through GLP-1 stabilization, J Clin Endocrinol Metab 98, E1163-1172, 2013

52. Ardestani,A, Paroni,F, Azizi,Z, Kaur,S, Khobragade,V, Yuan,T, Frogne,T, Tao,W, Oberholzer,J, Pattou,F, Kerr-Conte,J, Maedler,K: MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes. Nature Medicine, 2014

 

Book chapters

1. Maedler K, Dharmadhikari G, Schumann DM, Størling J.: Interleukin-targeted therapy for metabolic syndrome and type 2 diabetes. In Handb Exp Pharmacol. 2011;(203):257-78.

2. Amin Ardestani, Luan Shu and Kathrin Maedler: Targeting the metabolic syndrome and type 2 diabetes by preventing inflammation, Elsevier Book: NUTRITIONAL AND THERAPEUTIC INTERVENTIONS OF DIABETES AND METABOLIC SYNDROME 2011, In Press

3. Federico Paroni & Kathrin MaedlerCXCL10 Chemokine (C-X-C motif) ligand 10, Springer Book Encyclopedia of Signaling Molecules, 2011, In Press

Articles in conference proceedings

1. Maedler,K, Spinas,GA, Dyntar,D, Moritz,W, Kaiser,N, Donath,MY: Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. Proceedings of the EASD islet study group meeting, Eilat, Israel, 2000, Proceedings of the annual conference of the SGED, Bern, Switzerland, 2000

2. Dyntar,D, Eppenberger-Eberhardt,M, Maedler,K, Pruschy,M, Eppenberger H.M., Spinas G.A., Donath,MY: Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes. Diabetes 49S148: A37, Proceedings of the annual conference of the SGED, Bern, Switzerland, 2000

3. Maedler,K, Spinas,GA, Lehmann,R, Kaiser,N, Donath,MY: Glucose induces ß-cell apoptosis via upregulation of the Fas-receptor in human islets: A Link Between Type 1 and Type 2 Diabetes: Diabetes 50S2: A349

4. Maedler,K, Spinas,GA, Lehmann,R, Donath,MY: Mono-unsaturated fatty acids prevent the deleterious effects of palmitate and of high glucose on human pancreatic ß-cell turnover: Proceedings of the EASD islet study group meeting, Glasgow, UK, 2001

5. Maedler,K, Fontana,A, Ris,F, Sergeev,P, Toso,C, Oberholzer,J, Lehmann,R, Bachmann,F, Tasinato,A, Spinas,GA, Halban,PA, Donath,MY: FLIP switches Fas-mediated glucose signaling in human pancreatic ß-cells from apoptosis to cell replication. Diabetes 51S2: A385, Proceedings of the annual conference of the SGED, Bern, Switzerland, 2001, Proceedings of the 1st Day of Clinical Research in USZ, Zurich, Switzerland, 2002,

6. Maedler,K, Sergeev,P, Ris,F, Oberholzer,J, Joller-Jemelka,HI, Spinas,GA, Kaiser,N, Halban,PA, Donath,MY: Glucose-induced ß-cell production of interleukin-1ß contributes to glucotoxicity in human pancreatic islets: Diabetologia 45S2: A31, Proceedings of the 1st Day of Clinical Research in USZ, Zurich, Switzerland, 2002, Proceedings of the Western Region Islet study group meeting, Victoria, Canada, 2002, Proceedings of the annual conference of the SGED, Bern, Switzerland, 2002

7. Maedler,K, Sturis,J, Lehmann,R, Spinas,GA, Donath,MY: The SUR1/Kir6.2 selective potassium channel opener NN414 prevents glucose-induced apoptosis in human pancreatic ß-cells. Diabetes 51S2: A386, Diabetologia 45S2: A85

8. Lehmann,R, Weber,M, Zuellig,R, Maedler,K, Donath,M, Pfamatter,T, Binswanger,U, Clavien,PA, Spinas,GA: First case of insulin-independence after simultaneous islet-kidney transplantation with Edmonton protocol: 1 year follow-up: Diabetes 51S2: A461

9. Dyntar,D, Sergeev,P, Eppenberger-Eberhardt,M, Maedler,K, Spinas,GA, Eppenberger,HM, Donath,MY: Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes: Proceedings of the 8th Cardiovascular Biology and Clinical Implications Meeting, Villars, Switzerland, 2002.

10. Sergeev,P, Dyntar,D, Eppenberger-Eberhardt,M, Maedler,K, Spinas,GA, Perriard,JC, Schaub,MC, Donath,MY: Analysis by microarray of the genes expressed by isolated adult rat cardiomyocytes treated with high glucose and fatty acids: Proceedings of the 8th Cardiovascular Biology and Clinical Implications Meeting, Villars, Switzerland, 2002. Proceedings of the annual conference of the SGED, Bern, Switzerland, 2002

11. Schumann,DM, Maedler,K, Sergeev,P, Spinas,GA, Donath,MY: FLIP prevents IL-1ß-induced ß-cell apoptosis, decreases endogenously produced IL-1ß and improves ß-cell secretory function: Proceedings of the JDRF meeting: Diabetes – A Focus on the Pancreatic Beta Cell, 2002, Ystad, Sweden, Proceedings of the annual conference of the SGED, Bern, Switzerland, 2002

12. Mohanty,S, Trüb,T, Maedler,K, Spinas,GA, Donath,MY, Niessen,M: IRS-2 increases ß-cell proliferation and decreases glucose induced apoptosis in isolated pancreatic islets: Proceedings of the 1st Joint Meeting of the EASD Islet Study Group and the Boston-Ithaca Islet Club, 2002, Proceedings of the annual conference of the SGED, Bern, Switzerland, 2002

13. Sergeev,P, Dyntar,D, Eppenberger-Eberhardt,M, Maedler,K, Spinas,GA, Perriard,JC, Schaub,MC, Donath,MY: Microarray analysis of the genes expressed in diabetic rat hearts: Proceedings of the USGEB 35th Annual Meeting, Davos, 2003

14. Sergeev,P, Dyntar,D, Eppenberger-Eberhardt,M, Maedler,K, Spinas,GA, Perriard,JC, Schaub,MC, Donath,MY: Analysis of Gene expression regulation in the diabetic rat heart: Diabetes 52S2: A166, 2003

15. Schumann,DM, Maedler,K, Sergeev,P, Spinas,GA, Donath,MY: FLIP improves ß-cell secretory function, Diabetes 52S2: A338, 2003

16. Maedler,K, Bucher,P, Berney,T, Spinas,GA, Carr,RD, Donath,MY: Differential effects of repaglinide, nateglinide and glibenclamide on apoptosis in human ß-cells in vitro: Diabetes 52S2: A355, 2003

17. Maedler,K, Sergeev,P, Bucher,P, Berney,T, Spinas,GA, Dayer,JM, Halban,PA, Donath,MY: The Interleukin-1 receptor antagonist is expressed by human pancreatic ß-cells and decreased in type 2 diabetes: Diabetes 52S2: A355, Proceedings of the 2nd Day of Clinical Research in USZ, Zurich, Switzerland, 2003

18. Lehmann,R, Weber,M, Zuellig,R, Schwegler,B, Maedler,K, Donath,MY, Spinas,GA: Islet graft and kidney function in combined islet-kidney transplantation under a glucocorticoid-free imunosuppression (Edmonton protocol): Diabetes 52S2: A66, 2003

19. Hammar,E, Parnaud,G, Bosco,D, Maedler,K, Donath,MY, Halban,PA, Rouiller,DG: 804G matrix protects primary pancreatic ß-cells against apoptosis by increased expression of I-B and/or via activation of Akt: Diabetes 52S2: A353, 2003

20. Mohanty,S, Trüb,T, Maedler,K, Zuellig,RA, Lehmann,R, Spinas,GA, Niessen,M: Role of IRS-2 in ß-cell proliferation and apoptosis in isolated pancreatic islets: Diabetes 52S2: A361, 2003

21. Maedler,K, Donath,MY: Sensitivity to glucose-induced v-cell apoptosis increases with aging and correlates with appearance of FasL: Experimental Diabesity Research 4(3), 164, 2003

22. Hammar,E, Parnaud,G, Bosco,D, Maedler,K, Donath,MY, Rouiller,DG, Halban,PA: Signaling pathways in protection of primary pancreatic ß-cells against apoptosis by extracellular matrix: Proceedings of the annual conference of the SGED, Bern, Switzerland, 2003

23. Maedler,K, Sergeev,P, Bucher,P, Berney,T, Spinas,GA, Dayer,JM, Halban,PA, Donath,MY: The modulation of the Interleukin-1 receptor antagonist in human pancreatic ß-cells. Proceedings of the 3rd Day of Clinical Research in USZ, Zurich, Switzerland, 2003

24. Maedler,K, Sergeev,P, Reinecke,M, Mathe,Z, Berney,T, Dayer,JM, Halban,PA, Donath,MY. Leptin induces ß cell toxicity via modulation of IL-1ß and IL-1 receptor antagonist in human islets: Proceedings of the 3rd Day of Clinical Research in USZ, Zurich, Switzerland, 2004, Diabetes 53S2: A52, 2004

25. Maedler, K and Donath, MY, Sensitivity to glucose-induced ß-cell apoptosis increases with aging and correlates with appearance of FasL, Proceedings of the Western Region Islet study group meeting, Catalina Island, CA, USA, 2004.

26. Ellingsgaard,H, Schumann,D, Maedler,K, Ehses,J, Donath,MY. Glucotoxicity and IL-1beta secretion in mouse islets Diabetes 53S2: A375, 2004, Proceedings of the 3rd Day of Clinical Research in USZ, Zurich, Switzerland, 2004

27. Eve Zeender, Kathrin Maedler, Domenico Bosco, Thierry Berney, Marc Y. Donath and Philippe A. Halban. Pioglitazone and Sodium Salicylate Protect Human ß-cells Against Glucose- and IL-1ß- Induced Apoptosis and Impaired Function Diabetes 53S2: A376, 2004.

28. Schumann,D, Maedler,K, Chervonsky,AV, Donath,MY. The Fas Pathway is involved in Insulin Synthesis:Diabetes 53S2: A399, 2004, Proceedings of the 3rd Day of Clinical Research in USZ, Zurich, Switzerland, 2004

29. K. Maedler, D.M. Schumann, D. Bosco, Y. Iwakura, M.Y. Donath. Interleukin-1ß is a physiological regulator of beta-cell proliferation and secretory function: Diabetologia 47S1, A157

30. Hammar,E, Irminger,JC, Ribaux,G, Parnaud,G, Bosco,D, Rickenbach,K, Maedler,K, Donath,MY, Rouiller,DG, Halban,PA,: Activation of NF-B by extracellular matrix in primary rat pancreatic ß-cells. Diabetologia 47S1, A163

31. Halban,PA, Maedler,K, Zeender,E, Bosco,D, Berney,T, Donath,MY,. Pioglitazone and Sodium Salicylate Protect Human β-Cells against Apoptosis and Impaired Function Induced by Glucose and Interleukin-1β: Diabetologia 47S1, A174

32. Schumann,D, Maedler,K, Franklin,I, Sergeec,P, Chervonsky,AV, Wollheim,C, Donath,MY. The Fas Pathway is involved in Insulin Synthesis:Diabetes 53S2: A399, 2004, Proceedings of the 3rd Day of Clinical Research in USZ, Zurich, Switzerland, 2004

33. Levendal,RA, Maedler,K, Donath,MY, Crowther,NJ, Frost,CL, The effect of cannabis sativa on fat and glucose metabolism in obese and lean Wistar rats, Diabetologia 47S1, A290, 2004

34. Maedler,K, Schumann,DM, Donath,MY. With increasing age, human β-cell are more sensitive to glucose induced apoptosis: DIABETES UND STOFFWECHSEL 14 / 2005, 50

35. Maedler,K, Schumann,DM, Iwakura,Y, Donath,MY. Interleukin-1ß is a physiological regulator of beta-cell proliferation and secretory function: DIABETES UND STOFFWECHSEL 14 / 2005, 50

36. Maedler,K, Schumann,DM, Iwakura,Y, Donath,MY. The physiological role of Interleukin-1ß is mediated by IL-1Ra: Diabetes 54S1, A1608, 2005

37. Maedler,K, Bielmann,C, Bonny,C, Donath,MY, Roduit,R. Leptin and glucose induce β-cell apoptosis through activation of c-Jun N-terminal Kinases (SAPK/JNK): Diabetes 54S1, A1617, 2005

38. Schulthess,F, Sauter,NS, Oberholzer,J, Maedler,K. The direct role of IP-10 on beta cell apoptosis and function in type two diabetes, Proceedings of the Western Region Islet study group meeting, San Diego, CA, USA, 2005 & UCLA Department of Medicine Research Day, 2005, Los Angeles, CA, USA

39. Sauter,NS, Schulthess,F, Oberholzer,J, Maedler,K. Inhibition of ERK1/2 activation by chronically elevated glucose levels is responsible for the effects of glucose desensitization in human pancreatic islets. Proceedings of the Western Region Islet study group meeting, San Diego, CA, USA, 2005 & & UCLA Department of Medicine Research Day, 2005, Los Angeles, CA, USA

40. Maedler,K, Schumann,DM, Sauter, N, Iwakura,Y, Donath,MY. Interleukin-1ß is a physiological regulator of β-cell proliferation and insulin secretion: Proceedings of the UCLA Department of Medicine Research Day, 2005, Los Angeles, CA, USA

41. Schulthess,F, Sauter,NS, Oberholzer,J, Maedler,K. IP-10 Induces Beta-Cell Apoptosis and Impaired Function by an AKT Dependent Pathway: Diabetes 55S1, A1534, 2006

42. Sauter,NS, Schulthess,F, Maedler,K. IL-1Ra Protects Against Nutrition-Induced Diabetes: Diabetes 55S1, A1533, 2006

43. Schumann,D, Maedler,K, Franklin,I, Sergeec,P, Chervonsky,AV, Wollheim,C, Donath,MY. The Fas-FLIP Pathway Regulates Β-Cell Secretory Function Via NFkB and Pdx-1: Diabetes 55S1, A1647, 2006

44. Li,Y, Maedler,K, Haataja,L. UCP-2 and UCP-3 Are Differentially Regulated in Human Beta-Cells: Diabetes 55S1, A2547, 2006

45. Schulthess,F, Sauter,NS, Oberholzer,J, Maedler,K. The chemokine IP-10 as a mediator of decreased β-cell mass in diabetes: Diabetologia 49S1, 0420, 2006

46. Sauter,NS, Schulthess,F, Maedler,K. The anti-inflammatory cytokine IL-1Ra protects from nutrition-induced hyperglycemia and impaired glucose tolerance: Diabetologia 49S1, 0509, 2006

47. Kosik R, Sauter N, Schulthess F, Maedler, K: Expression of SOCS-3 protects pancreatic beta cells from glucose and interleukin-1 beta-induced apoptosis. Proceedings of the UCLA Department of Medicine Research Day, 2006, Los Angeles, CA, USA

48. Sauter,NS, Schulthess,FT, Maedler,K. IL-1Ra is down-regulated in Diabetes, Proceedings of the UCLA Department of Medicine Research Day, 2006, Los Angeles, CA, USA

49. Schulthess,F, Sauter,NS, Oberholzer,J, Maedler,K. IP-10 is a ligand for TLR4 in pancreatic beta-cells. Proceedings of the UCLA Department of Medicine Research Day, 2006, Los Angeles, CA, USA

50. Muehle, M, Schulthess,FT, Maedler,K, TOSO protects from beta-cell apoptosis and is downregulated in diabetes. Proceedings of the UCLA Department of Medicine Research Day, 2006, Los Angeles, CA, USA

51. Kosik R, Sauter N, Schulthess F, Maedler, K: Expression of SOCS proteins protects pancreatic beta cells from glucose and interleukin-1 beta-induced apoptosis. JOURNAL OF INVESTIGATIVE MEDICINE Volume: 55 Issue:1: S124-S124, 2007

52. Schulthess FT, Quiros MA, Nebohacova M, Maedler, K: 5-lipoxygenase is a regulator of insulin secretion: DIABETES Volume: 56, A410-A410: Suppl. 1, JUN 2007

53. Sauter NS, Schulthess FT, Galasso R, Maedler,K: The anti-inflammatory cytokine interleukin-1 receptor antagonist protects from high fat diet induced diabetes by maintaining PDX-1 activity: DIABETES, Volume: 56, A27-A27: Suppl. 1: JUN 2007

54. Chen D, Sauter NS, Zamudio V, Schulthess FT, Shu L, Schumann DM, Maedler K, Do changes in the balance of pro- and anti-inflammatory cytokines regulate β-cell mass in diabetes? Proceedings of the UCLA Department of Medicine Research Day, 2007, Los Angeles, CA, USA

55. Shu L, Sauter NS, Schulthess FT, Maedler K: TCF7L2 regulates β-cell survival, Proceedings of the UCLA Department of Medicine Research Day, 2007, Los Angeles, CA, USA

56. Sauter NS, Schulthess FT, Maedler K: The anti-inflammatory cytokine interleukin-1 receptor antagonist improves beta cell function and survival by maintaining nuclear PDX-1 expression, Proceedings of the UCLA Department of Medicine Research Day, 2007, Los Angeles, CA, USA

57. Schulthess FT, Mehrabian, M, Nebohacova M, Maedler, K: 5-lipoxygenase is a regulator of insulin secretion, Proceedings of the UCLA Department of Medicine Research Day, 2007, Los Angeles, CA, USA

58. Owyang A, Gross L, Shu L, Esposito L, Maedler, K, Kantak S. XOMA 052, an Anti-IL-1β Antibody, Preserves Beta-Cell Function and Reduces Hyperglycemia in the Diet-Induced Obesity Mouse Model of Type 2 Diabetes. DIABETES, Volume: 57, late braking abstracts: Sl. 1: JUN 2008

59. Sauter NS, Schulthess FT, Maedler K: The anti-inflammatory cytokine interleukin-1 receptor antagonist improves beta cell function and survival by maintaining nuclear PDX-1 expression, DIABETOLOGIA Volume: 51. S310-S311 Supplement: S1: SEP 2008

60. Maedler K, Sauter NS, Schulthess FT The chemokine IP-10 induces beta cell death through TLR4-signalling: DIABETOLOGIA Volume: 51: S312-S312, S1, 781 SEP 2008

61. Schulthess,F, Maedler,K. IP-10 is a ligand for TLR4 and regulated beta-cell survival in diabetes. Proceedings of the Annual Meeting of the Larry L Hillblom Research Foundation, Newport Beach, CA, USA, 2008

62. Zamudio V, Sauter NS, Chen D, Maedler K: Knocking out IL-I beta signaling: a cure for diabetes? JOURNAL OF THE AMERICAN GERIATRICS SOCIETY Volume: 56, 4, S204-S204.: APR 2008

63. Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CHS, Maedler K: Decreased TCF7L2 protein levels in T2DM correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. DIABETES, Volume: 58, Sl. 1: 1160, 2009

64. Owyang A, Maedler K, Gross L, Shu L, Jadhav J, Shu L, Esposito L, Kantak S.: XOMA 052, an Anti-IL-1β Antibody, Preserves Beta-Cell Function and Reduces Hyperglycemia in the Diet-Induced Obesity Mouse Model of Type 2 Diabetes. DIABETES, Volume: 58, Sl. 1: 310, 2009

65. Shu, L; Matveyenko, AV; Kerr-Conte, J, … Maedler K: Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlated with downregulation of GIP and GLP-1 receptors and impaired beta cell function DIABETOLOGIA Volume: 52 Pages: S38-S38 Published: 2009

66. Dharmadhikari, G; Muehle, MK; Schulthess, FT,…Maedler K: The Fas apoptotic inhibitory protein TOSO induces proliferation in human beta cells. DIABETOLOGIA Volume: 52 Pages: S88-S88 Published: 2009

67. Ardestani, A; Sauter, NS; Kerr-Conte, J,…Maedler K: PDX-1 translocates to the cytosol in type 2 diabetes. DIABETOLOGIA Volume: 52 Pages: S89-S90 Published: 2009.

68. Göhring, N. Sauter, G. Catchpole, A. Assmann, M. Moehlig, A. F. Pfeiffer, J. Oberholzer, L. Willmitzer, K. Maedler, J. Spranger: Identifizierung des intrazellulären Metabolitenprofils, welches an der glukotoxischen Betazell-Fehlfunktion beteiligt ist (V II-13): German Society of Nutrition

69. Goehring, N. Sauter, G. Catchpole, A. Assmann, A. Fischer-Rosinsky, J. Oberholzer, L. Willmitzer, K. Maedler, J. Spranger: Unbiased metabolite profiling reveals that pentose phosphate pathway metabolites contribute to impaired beta-cell function in an ERK1/2 dependent fashion (P70); 1st International Metabolomics Symposium in Germany, Metabolomics & More, Freising-Weihenstephan

70. Mee L, Nabokina S, Maedler K, et al.: Mechanisms and Regulation of Vitamin B1 (Thiamin) Uptake By Mouse and Human Pancreatic Cells, GASTROENTEROLOGY, Volume 136, 5, p A277, 2009

71. Sauter N, Goehring I, Catchpole G, A. Assmann, A. Fischer-Rosinsky, J. Oberholzer, L. Willmitzer, K. J. Spranger, Maedler, K: Metabolomic Profiling in human islets. DIABETOLOGIA , Volume: 53, S35, 2010

72. Domsgen E, Paroni F, Kerr-Conte J, Maedler K: Virus-induced beta cell death depends on CXCL10 and the AKT-JNK-PKR crosstalk, DIABETOLOGIA, Volume: 53, S186, 2010

73. Dharmadhikari G, Paroni F, Kerr-Conte J, Kelm S, Maedler K, Siglecs are differentially expressed in pancreatic islets and regulate beta cell function and survival, DIABETOLOGIA, Volume: 53, S207, 2010

74. Ardestani A, Paroni F, Kerr-Conte J, Maedler K, MST1 mediates beta cell apoptosis and impaired function, DIABETOLOGIA, Volume: 53, S208, 2010

75. Shah P, Schumann DM, Ardestani A, Madler K: The DPP-4 Inhibitor Linagliptin Restores beta-Cell Function in Human Isolated Islets, DIABETES, Volume: 59, p: A457, 2010

76. Lee S, Owyang AM, Gross L, El Bader S, Yin J, Bhaskar V, Maedler K, Kantak S: Combination Studies of the Anti-Interleukin-1beta Monoclonal Antibody XOMA 052 with Exendin-4 or Sitagliptin in a Diet-Induced Obesity Mouse Model of Type 2 Diabetes Mellitus DIABETES Volume: 59, p: A474, 2010

     

77. Owyang AM, Lee S, Gross L, Phan D, Yin J, El Bader S, Bhaskar V, Maedler K, Mirza A, Kantak S, Inhibition of Interleukin-1beta with the Monoclonal Antibody XOMA 052 Reveals the Differential Sensitivities of Glycemic and Pancreatic Function Parameters to Chronic Inflammation, DIABETES Volume: 59, p: A476, 2010

78. Le Bacquer O.; Shu L.; Marchand M.; et al., Alternative splicing of TC7L2 and beta-pancreatic function DIABETES & METABOLISM Volume: 37 Pages: A1-A2 2011

79. Mammalian sterile 20-like kinase 1 (MST1) mediates pancreatic β-cell apoptosis, Amin Ardestani, Federico Paroni, Julie Kerr-Conte* and Kathrin Maedler, Diabetes 2011, S1

80. Endosomal TLR3 activation initiates virus-induced b-cell death, Federico Paroni1, Erna Domsgen1, Julie Kerr-Conte2, Andreas Dotzauer1 and Kathrin Maedler, Diabetes 2011, S1

     

81. Endosomal TLR3 activation by Coxsackievirus initiates strong immune response and death of beta cells E. Domsgen1, F. Paroni1, J. Kerr-Conte2, A. Dotzauer1, K. Maedler1; Diabetologia 2011, S1

82. FABP5 depletion protects from gluco- and lipotoxicity in beta cells K.S. Zien, M. Vaidya, G. Dharmadhikari, F. Paroni, K. Maedler; Diabetologia 2011, S1

83. Siglec 7 improves beta cell function and survival by inhibition of cytokine expression and secretion G. Dharmadhikari1, F. Paroni1, J. Kerr-Conte2, S. Kelm1, K. Maedler1; Diabetologia 2011, S1

84. K. Maedler1, J. Kerr-Conte2, L. Shu1: TCF7L2 plays a role in beta cell regeneration. Diabetologia 2011, S1, 407

85. Coxsackievirus initiates strong immune response and death of beta cells E. Domsgen, F. Paroni, J. Kerr-Conte, A. Dotzauer, K. Maedler; Diabetologia 2012, S1

86. CXCL10 antagonism improves insulin sensitivity, inflammation, beta cell function, survival and mass, P. Shah, E. Domsgen, J. Bergemann, P. Janssen, N. Stappenbeck, P. Cardarelli, K. Maedler, Diabetologia 2012, S1

87. FABP5 depletion protects from STZ induced diabetes K. Zien, J. Bergemann, A. Meyer, Y. Owada, K. Maedler; Diabetologia 2012, S1

88. A. Ardestani, F. Paroni, J. Kerr-Conte, K. Maedler; MST1 mediates beta cell failure by targeting BIM and destabilising PDX1, Diabetologia 2012, S1

89. A. Meyer, E. Kuestermann, K. Stolz, J. Bergemann, W. Dreher, K. Maedler; Non-invasive in vivo analysis of beta cell function and mass by MRI, Diabetologia 2012, S1

90. The adipocytokines Nampt and vaspin have no effect on beta cell survival but potentiate glucose stimulated insulin secretion, K. Stolz, R. Spinnler, T. Gorski, S. Laue, S. Schuster, A. Garten, J. Kratzsch, P. Kovacs, J. Heiker, A. Beck-Sickinger, E. de Koning, A. Körner, W. Kieß, K. Maedler, Diabetologia 2012, S1

91. Siglec-7 expression decreases in freshly isolated peripheral blood mononuclear cells (PBMCs) under diabetogenic conditions , Dharmadhikari, G.; Stolz, K.; Kraemer, A., Kelm, S., Maedler K.: IMMUNOLOGY Volume: 137 Special Issue: SI Supplement: 1 Pages: 310-310 Published: SEP 2012

92. Park YJ, Maedler K, Ao Z, Safikhan N, Warnock GL, Marzban L. Blocking IL-1 receptor reduces amyloid formation and enhances beta-cell survival and function in cultured human islets. The American Diabetes Association Annual Meeting, Chicago, USA, June 2013. Diabetes 62 S1, 2162, 2013.

93. Dharmadhikari, G.; Kerr-Conte, J.; Kelm, S.; et al.Siglec-7 is down-regulated in inflamed islets and activated peripheral mononuclear cells and restores beta cell function and survival , 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD) Location: Barcelona, SPAIN, DIABETOLOGIA Volume: 56 S1, S338-S339, 2013

94. Shah, P.; Olerud, J.; Kerr-Conte, J.; et al., Angiogenic factors regulate beta cell function , 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD) Location: Barcelona, SPAIN, DIABETOLOGIA Volume: 56 S1, S338-S339, 2013