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smallest dose level whose expected response is larger than the placebo response by some pre-specified margin) or estimation of the median effective dose (ED50). Two approaches exist for the analysis of phase
Bereich: FB3
(2013). Group sequential designs for three-arm ’gold standard’ non-inferiority trials with fixed margin. Statistics in Medicine, 32(28):4875-4889 Wang SJ, Brannath W, Brueckner M, Hung HML, Koch A (2013)