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Faculty 3 - Mathematics and Computer Science: Competence Center for Clinical Trials Bremen

Dr. Martin Scharpenberg

portrait photo of Doctor Martin Scharpenberg
© KKSB

Project Responsibility

Room:41 120
Phone:+49(0)421 218-63789
E-Mail:mscharpenbergprotect me ?!uni-bremenprotect me ?!.de
Office hours:by appointment

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  • Statistical support in planning and analysis of clinical trials
  • Preparation of study protocols, statistical analysis plans and statistical reports
  • Sample Size calculation and randomization
  • Programming of statistical evaluations in SAS and R
  • Mathematical/statistical research
  • Responsible for the study program "M.Sc. Medical Biometry/Biostatistics"
  • Teaching in Mathematics and "M.Sc. Medical Biometry/Biostatistics"
  • Statistical consulting
  • Association analysis (Mean Impact)
  • Simultaneous inference
  • Subgroup analyses
  • Non-linear regression
  • Weber F, Kloek CJJ, Neumann S, Bahns C, Boebinger H, Diedrich F, Dieter V, Gellert P, Kopkow C, Krauss I, Lech S, Luschei R, Pleus J, Rpschlaeger U, Rothgang H, Scharpenberg M, Thiel C, Valk-Draad M, Veenhof C, Vollmar HC, Peschke D, Grueneberg C (2026). Effectiveness of a blended care intervention in physiotherapy with exercise and education for patients with hip or knee osteoarthritis (SmArt-E): A multicentre pragmatic randomized controlled trial. Osteoarthritis and Cartilage, online first (https://doi.org/10.1016/j.joca.2026.06.010)
  • Brannath W, Kluge L, Scharpenberg M (2026). Informative simultaneous confidence intervals for graphical test procedures. Statistical Methods in Medical Research, 35 (1) (https://doi.org/10.1177/09622802251393)
  • Wiegand A, Mathmann P, Wasmuth S, Prein L, Parfitt R, Scharpenberg M, Jankovic V, Schwarze K, Neumann A, Schaefer K, Speckemeier C, Baessler S, Schlierenkamp S, Diekmann S, Stuhrmann N, Lang-Roth R, Demir M, Brannath W, Naghipour A, Zielonkowski S, Schwalen AS, Gietmann C, Neumann K (2026). Clinical Diagnostics After Failed Hearing Screening in People With Intellectual Disabilities Do Not Often Take Place. Journal of Intellectual Disability Research, Volume 70, Issue 4, 384-394 (https://doi.org/10.1111/jir.70078)
  • Zielonkowski S, Mathmann P, Naghiour A, Wasmuth S, Prein L, Parfitt R, Brannath W, Scharpenberg M, Jankovic V, Neumann A, Schwarze K, Schaefer K, Speckemeier C, Gietmann C, Neumann K (2025). Evaluating the Hearing-Related Quality of Life in People With Intellectual Disabilities. Journal of Intellectual Disability Research, Volume 69, Issue 12, 1413-1424 (https://doi.org/10.1111/jir.70036)
  • Limbrunner J, Doerfler J, Pietschmann K, Buentzel J, Scharpenberg M, Huebner J (2025). The influence of antioxidant supplementation on adverse effects and tumor interaction during radiotherapy: a systematic review. Clinical and Experimental Medicine, Volume 25, article number 258 (https://doi.org/10.1007/s10238-025-01804-x)
  • Schild R, Scharpenberg M, Rudolph I, Buentzel J, Huebner J (2025). Effect of Ballroom Dancing on the Physical, Psychological, and Mental Well-Being of Oncological Patients: A Pilot Study. International Journal of Environmental Research and Public Health, 22(4), 470 (https://doi.org/10.3390/ijerph22040470)
  • Hofinger J, Kaesmann L, Buentzel J, Scharpenberg M, Huebner J (2024). Systematic assessment of the influence of quality of studies on mistletoe in cancer care on the results of a meta-analysis on overall survival. Journal of Cancer Research and Clinical Oncology, 150, 219. (https://doi.org/10.1007/s00432-024-05742-1)
  • Yaron S, Rosenberg L, Hickerson W, Goverman J, Iyler N, Barrera-Oro J, Lipovy B, Monstrey S, Blome-Eberwein S, Wibbenmeyer LA, Scharpenberg M, Singer A (2023) Early Enzymatic Burn Debridement: Results of the DETECT Multicenter Randomized Controlled Trial. Journal of Burn Care & Research (https://doi.org/10.1093/jbcr/irad142
  • Scharpenberg M, Brannath W (2023) Simultaneous confidence intervals for an extended Koch-Röhmel design in three-arm non-inferiority trials. Statistical Methods in Medical Research. Online first (https://doi.org/10.1177/09622802231189592)
  • Alvarez-Molina K, Reinschlüssel AV, Kratky T, Scharpenberg M, Malaka R (2023) Can you feel the rhythm? Comparing vibrotactile and auditory stimuli in the rhythm video game Jump‘n'Rhythm. Behaviour & Information Technology. (https://doi.org/10.1080/0144929X.2023.2243525)
  • Schwarze K, Mathmann P, Schäfer K, Brannath W, Höhne P-H, Altin S, Prein L, Naghipour A, Zielonkowski SM, Wasmuth S, Kanaan O, am Zehnhoff-Dinnesen A, Schwalen AS, Schotenröhr A, Scharpenberg M, Schlierenkamp S, Stuhrmann N, Lang-Roth R, Demir M, Diekmann S, Neumann A, Gietmann C, Neumann K (2023) Effectiveness and costs of a low-threshold hearing screening programme (HörGeist) for individuals with intellectual disabilities: protocol for a screening study. BMJ Open 13:e070259 (https://doi.org/10.1136/bmjopen-2022-070259)
  • Brannath W, Scharpenberg M, Schmidt S (2022). Single-stage, three-arm, adaptive test strategies for non-inferiority trials with an unstable reference. Statistics in Medicine Available online 18 August 2022 (https://doi.org/10.1002/sim.9552)
  • Grill S, Ring A, Brannath W, Scharpenberg M (2020). Assessing consistency in clinical trials with two subgroups and binary endpoints: A new test within the logistic regression model. Statistics in Medicine Available online 26 October 2020 (http://dx.doi.org/10.1002/sim.8719)
  • Jilani H, Rathjen K I, Schilling I, Herbon C, Scharpenberg M, Brannath W, Gerhardus A (2020). Handreichung zur Patient*innenbeteiligung an klinischer Forschung, Version 1.0, Universität Bremen. Verfügbar unter: http://dx.doi.org/10.26092/elib/229
  • Rathjen K I, Herbon C, Jilani H, Scharpenberg M, Schilling I, Schmiemann G, Brannath W, Gerhardus A (2020). Aktive Beteiligung von älteren Patient*innen an klinischer Forschung (INVOLVE-Clin): Ein Studienprotokoll. ZEFQ Available online 27 August 2020 (https://doi.org/10.1016/j.zefq.2020.07.009)
  • Mirastschijski U, Schwab I, Coger V, Zier U, Rianna C, He W, Maedler K, Kelm S, Radtke A, Belge G, Lindner P, Stahl F, Scharpenberg M, Lasota L, Timm J (2020). Lung Surfactant Accelerates Skin Wound Healing: A Translational Study with a Randomized Clinical Phase I Study. Sci Rep 10, 2581 (https://doi.org/10.1038/s41598-020-59394-5)
  • Veselinović T, Scharpenberg M, Heinze M, Cordes J, Mühlbauer B, Juckel G, Rüther E, Paulzen M, Haen E, Hiemke C, Timm J, Gründer G (2019). Dopamine D2 Receptor Occupancy Estimated From Plasma Concentrations of Four Different Antipsychotics and the Subjective Experience of Physical and Mental Well-Being in Schizophrenia: Results From the Randomized NeSSy Trial. J Clin Psychopharmacol. Volume 39, Issue 6, pp. 550-560 (https://doi.org/10.1097/JCP.0000000000001131)
  • Veselinović T, Scharpenberg M, Heinze M, Cordes J, Mühlbauer B, Juckel G, Habel U, Rüther E, Timm J, Gründer G (2019). Disparate effects of first and second generation antipsychotics on cognition in schizophrenia - Findings from the randomized NeSSy trial. Eur Neuropsychopharmacol. Volume 29, Issue 6, pp. 720-739 (https://doi.org/10.1016/j.euroneuro.2019.03.014)
  • Ring A, Scharpenberg M, Grill S, Schall R, Brannath W (2018). Equivalence Tests in Subgroup Analyses. In: Zhao Y & Chen D-G (Eds.), New Frontiers of Biostatistics and Bioinformatics (pp. 201 - 238), Springer Nature Switzerland AG (https://doi.org/10.1007/978-3-319-99389-8_10)
  • Bauer A, Hausmann H, Schaarschmidt J, Szlapka M, Scharpenberg M, Eberle T, Hasenkam J M. Is 300 Seconds ACT Safe and Efficient during MiECC Procedures?. Prepublished December 31, 2017 (https://doi.org/10.1055/s-0037-1609019)
  • Bauer A, Hausmann H, Schaarschmidt J, Scharpenberg M, Troitzsch D, Johansen P, Nygaard H, Eberle T, Hasenkam J M (2018). Shed-blood-separation and cell-saver: an integral Part of MiECC? Shed-blood-separation and ints influence on the perioperative inflammatory response during coronary revascularization with minimal invasive extracorporeal ciculation systems - a randomized controlled trial. Perfusion. Vol 33, Issue 2, pp. 136 - 147 First Published September 22, 2017 (https://doi.org/10.1177/0267659117728195)
  • Scharpenberg M (2015). Non-Linear Mean Impact Analysis. Dissertation. Bremen (http://nbn-resolving.de/urn:nbn:de:gbv:46-00104597-18)
  • Brannath W, Scharpenberg M (2014). Interpretation of linear regression coefficients under mean model miss-specifications. (http://arxiv.org/abs/1409.8544v4[stat.ME])
  • M. Scharpenberg, S. Schmidt, W. Brannath (2021): Single-stage, three-arm, adaptive test strategies for non-inferiority trials with an unstable reference. 67. Biometrisches Kolloquium der Deutschen Region der Internationalen Biometrischen Gesellschaft (IBS-DR). Online
  • M. Scharpenberg, J. Timm (2015): Termination of thoracic drainages - a biometric approach. 60. Jahrestagung der GMDS e.V. Krefeld
  • M. Scharpenberg, W. Brannath (2014): Overall quantification of non-linear dependencies. 35th annual Conference of the International Society for Clinical Biostatistics (ISCB35). Wien
  • M. Scharpenberg, W. Brannath (2014): Overall quantification of non-linear dependencies. 60. Biometrisches Kolloquium der Deutschen Region der Internationalen Biometrischen Gesellschaft (IBS-DR). Bremen
11/2020Certificate "Biometry in Medicine" of the German Association for Medical Informatics, Biometry and Empidemiology (GMDS) and the German Region of the International Biometric Society (IBS-DR)
2020-2024Secretary and board member of the German Region of the International Biometric Society (IBS-DR)
2020-2022Deputy member of the ethics committee of the Federal State of Bremen
since 01/2016Academic Councilor at the department of mathematics
10.07.2015Doctorate in Mathematics
05/2012-12/2015Research associate at the KKSB
26.01.2013"Fachbereichspreis Mathematik"
11.04.2012Diploma Mathematics
2007-2012Studies in Mathematics at the University of Bremen

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Updated by: Jörg Bendig
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