Research Highlights

Gold Nanoparticle-Coated Bioceramics for Plasmonically Enhanced Molecule Detection via Surface-Enhanced Raman Scattering

Tongwei Guo, Jonas Schmidt, Mohammad Mangir MurshedKurosch RezwanMichael Maas

Advanced Engineering Materials (2023): 2300942

Herein, feasibility of plasmonically enhanced molecule detection via surface-enhanced Raman scattering for ceramics that are commonly used as bone ortooth replacement materials is evaluated. Open cell foams of Bioglass 45S5, thecommercial hydroxyapatite-based product Bio-Oss, and bioinert zirconia-toughened-alumina (ZTA) are coated with Au nanoparticles via colloidal depo-sition to introduce plasmonic effects. Depending on the pore size, gold-func-tionalized plasmonic porous Bioglass shows effective Raman enhancementfactor (eEF) up to 5.4·104, while depositing gold nanoparticles on Bio-Oss andporous ZTA resulted in eEF of 1.1·104 and 2.4·105 respectively. The per-formance of the plasmonic porous bioceramics under simulated biologicalconditions is examined in situ in the biological medium fetal bovine serum (FBS)and during extended incubation in mineralizing simulated bodyfluid (SBF). Mostnotably, the plasmonic porous Bioglass still delivered an eEF around 7.2·103 after 28 days of incubation in SBF, indicating promising stability in simulatedbiological conditions without significant difference in SBF bioactivity before andafter Au deposition. Accordingly, the plasmonically enhanced porous bioceramicsoffer the possibility for real-time and sensitive molecule detection at SBF and FBSconditions and can be further developed for sensing of specific biomarkers, forexample, in the context of osseointegration of bone replacement materials.

Figure from the paper of Guo et al.
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