ESR11
to which the ordering can depend on the data, this strategy includes the sequential t-test as well as the Dunnett test as special cases. While the calculation of confidence intervals is mandatory in many [...] the minimal effective dose, is then based on pairwise comparisons with statistical significance testing. Depending on the size of the study, multiplicity adjustment may be applied to the comparisons. Such [...] significant results before considering comparisons of lower ordering (for example, performing sequential t-test of decreasing dose levels against a placebo zero dose). An interesting combination of these two adjustment