Islet Research
stress, hyperactivation and hypernutrition. The beta-cell has a very limited capacity to compensate for such environmental stress factors. With the identification of disturbances in the Hippo developmental pathway [...] and interacts and crosstalks with many other signaling pathways, which regulate beta-cell survival, such as the intrinsic apoptotic pathway, mTOR, PI3K-AKT and MAPK-JNK to respond to exogenous and endogenous