Dr. Frank Dietz
- 1997 Diploma in Biology at the Department of Biochemistry of the Christian-Albrechts University of Kiel, Germany - Title of the Diploma Thesis: "Design of enzyme derivatives to overcome the blood-brain barrier" (German)
- 2000 Dissertation at the Department of Physiological Chemistry of the Rheinische-Friedrich-Wilhelm University of Bonn, Germany - Thesis Title: "Isolation and identification of Arylsulfatase A-mRNA-binding proteins from bovine testis" (German)
- 2001 - 2006 Assistent Professor ("Wissenschaftlicher Assistent", C1) at the Centre for Biomolecular Interactions Bremen (CBIB), Department of Biochemistry, University of Bremen, Germany
- Since 2007 Senior Research Associate ("Akademischer Rat") at the Centre for Biomolecular Interactions Bremen (CBIB), Department of Biochemistry, University of Bremen, Germany
Our main research focus is on a group of proteins comprising the hepatoma-derived growth factor (HDGF), the HDGF-related proteins 1 - 4 (HRP-1-4) and the lens epithelium-derived growth factor (LEDGF). All members belong to a growing number of proteins containing the PWWP-domain which is located in a highly conserved 100 amino acids spanning N-terminal region, called the hath-region (homologues to the amino-terminus of HDGF). With the aid of nuclear localization signals (NLS) the proteins are predominantely located to the nucleus. Interestingly, very little is known about the exact functions of most of the members within the cell and especially about the functions in different cell types or tissues. Growth promoting activity, unknown routes of secretion and internalization are some of the characteristics which have been identified. Furthermore, HDGF and probably other HRPs seem to play an important role in different forms of cancer.
Using a variety of biochemical and cell biology methods in close cooperation with different working groups, we are investigating protein/protein interactions, post-translational modifications (SUMOylation, Phosphorylation or O-GlnAc), oxidative stress response, subcellular trafficing etc. to get a better understanding of the functions and the functional regulations of these proteins within the cell.